Testing RO7890597 safety and how it moves through the body in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 1 interventional trial in healthy volunteers. It uses single ascending doses and multiple ascending doses to explore safety and pharmacokinetics, with additional arms to examine the effects of food and proton pump inhibitors, plus a drug-drug interaction assessment. Participants may receive RO7890597 or placebo, with monitoring for adverse events and changes in drug levels. The study is conducted at a single site in Lenexa, Kansas, led by Genentech."

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Agreement to adhere to the contraception requirements.
* Body mass index of 18 to 30 kilograms per square meter (kg/m²).

Exclusion Criteria:

* Pregnant, breastfeeding, or intending to become pregnant during the study or required contraception period.
* Treatment with investigational biologic therapy within 90 days or 5 elimination half-lives, whichever is longer, before study drug initiation.
* Treatment with investigational non-biologic therapy within 28 days or 5 elimination half-lives, whichever is longer, before study drug initiation.
* Treatment with immunosuppressive medication within 28 days or 5 elimination half-lives, whichever is longer, before study drug initiation.
* Treatment with any vaccine within 14 days prior to initiation of study drug, or within 28 days for a live or live attenuated vaccine.
* Poor peripheral venous access.
* Major surgery within 28 days before study drug initiation or planned major surgery during the study.
* Current infection or recent infection requiring antibiotics as defined in the protocol.
* History of malignancy within 5 years before screening, except for specified adequately treated cancers.
* History of clinically significant drug or food allergy.

Where it's running

• ICON (LPRA) - Lenexa
  Lenexa, Kansas, United States Recruiting

Study contacts

• Study coordinator: Reference Study ID Number: GA46708 https://forpatients.roche.com/ No attachments to email below.
• Email: global-roche-genentech-trials@gene.com
• Phone: 888-662-6728 (U.S. and Canada)

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.