Testing potassium supplements to improve heart health
The Role of Potassium Supplementation on Endothelial Function, BP Regulation, and Oxidative Stress Under High Sodium Conditions
NA · University of Delaware · NCT05887622
This study is testing if taking potassium supplements can help healthy adults counteract the negative effects of a high sodium diet on their heart and blood vessels.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | University of Delaware (other) |
| Locations | 1 site (Newark, Delaware) |
| Trial ID | NCT05887622 on ClinicalTrials.gov |
What this trial studies
This study investigates whether potassium supplementation can mitigate the negative effects of a high sodium diet on blood vessel function, blood pressure reactivity, and autonomic nervous system function in healthy adults. It aims to determine if a high potassium intake can enhance endothelial function and reduce oxidative stress compared to a low potassium intake while consuming a high sodium diet. The study will utilize flow-mediated dilation, cold pressor tests, and isometric handgrip tests to assess vascular function and oxidative stress levels. This research is crucial as it addresses early intervention strategies for cardiovascular disease prevention in a population that may not yet exhibit clinical symptoms.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 18-45 with a BMI under 30 and normal blood pressure.
Not a fit: Patients with hypertension, heart disease, diabetes, kidney disease, or other specified health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a dietary intervention to improve cardiovascular health and prevent disease in individuals at risk due to high sodium intake.
How similar studies have performed: While studies have shown benefits of high potassium diets, this specific approach of supplementation in healthy adults is relatively novel and underexplored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * men and women * 18-45 years of age * all races/ethnicities * BMI \< 30 kg/m2 * BP \< 130/80 mmHg Exclusion Criteria: * presence of hypertension * known heart disease * diabetes * kidney disease * cancer * inflammatory conditions * blood clotting disorders * pregnancy * adrenal gland disorder * history of stomach or intestinal bleeding * history of kidney stones * serum potassium outside of the normal range
Where this trial is running
Newark, Delaware
- Tower at STAR — Newark, Delaware, United States (RECRUITING)
Study contacts
- Study coordinator: Shannon L Lennon, PhD
- Email: slennon@udel.edu
- Phone: 3023824291
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiovascular Health, Cardiovascular Risk Factor