Testing how salt affects blood pressure
Diagnostic Accuracy of Using an Immediate Pressor Response to Oral Salt (IPROS) to Identify Salt Sensitivity of Blood Pressure (SSBP): a Time Series Clinical Trial
This study tests how eating different amounts of salt affects blood pressure in people to see if they are sensitive to salt.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Mulungushi University Academic / other |
| Locations | 2 sites (Livingstone, Southern and 1 other locations) |
| Trial ID | NCT06226636 on ClinicalTrials.gov |
What this trial studies
This study aims to determine the diagnostic accuracy of the immediate pressor response to oral salt (IPROS) in identifying individuals with salt sensitivity of blood pressure (SSBP). Participants will consume dietary salt, and their blood pressure will be monitored every 10 minutes for two hours to assess the immediate response. Additionally, participants will follow a high salt diet for one week and a low salt diet for another week, with mean arterial pressure differences used to diagnose SSBP. The study focuses on understanding how dietary salt impacts blood pressure regulation.
Who should consider this trial
Good fit: Ideal candidates are healthy males and females aged 18-65 years without kidney or cardiovascular diseases.
Not a fit: Patients with existing kidney disease or cardiovascular disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify individuals who are salt-sensitive, leading to better management of high blood pressure.
How similar studies have performed: Other studies have explored salt sensitivity in blood pressure, but the specific approach of this study may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants will be included if they are males or females, aged 18-65 years. Exclusion Criteria: * Kidney disease, Cardiovascular disease
Where this trial is running
Livingstone, Southern and 1 other locations
- Livingstone University Teaching Hospital — Livingstone, Southern, Zambia (Not_yet_recruiting)
- Kanyama General Hospital — Lusaka, Zambia (Recruiting)
Study contacts
- Study coordinator: Sepiso K Masenga, PhD
- Email: sepisomasenga@gmail.com
- Phone: +260977674774
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.