Testing for pneumococcus pneumoniae in patients with community-acquired pneumonia
Prospective Study to Evaluate Stretococcus Pneumoniae Serotype Prevalence in Community Acquired Pneumonia in Hong Kong Using a Urinary Kit
This study is trying to see how common a specific bacteria called Streptococcus pneumoniae is in people hospitalized with pneumonia that they caught outside of the hospital.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1800 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Shatin) |
| Trial ID | NCT05374018 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the prevalence and serotypes of Streptococcus pneumoniae in hospitalized patients diagnosed with community-acquired pneumonia (CAP). It utilizes a urinary antigen assay to identify the specific serotypes of the bacteria in patients presenting with pneumonia symptoms. The study will include patients who show signs of pneumonia, such as fever and respiratory symptoms, while excluding those with hospital-acquired pneumonia or known infections from other pathogens. The findings could provide valuable epidemiological data on pneumococcus pneumoniae in the community.
Who should consider this trial
Good fit: Ideal candidates for this study are hospitalized patients exhibiting symptoms of community-acquired pneumonia.
Not a fit: Patients with pneumonia acquired after 48 hours of hospital admission or those with infections caused by pathogens other than pneumococcus pneumoniae may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of pneumococcus pneumoniae serotype prevalence, potentially guiding more effective treatment and prevention strategies for pneumonia.
How similar studies have performed: While this study focuses on a specific aspect of pneumonia epidemiology, similar studies have shown success in identifying bacterial serotypes and their prevalence in various populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Admitted with signs and symptoms suggestive of pneumonia which include one or more of the followings: 1. fever 2. CXR changes with consolidation, increased alveolar shadowing or hazziness 3. respiratory symptoms like increase shortness of breath, cough with sputum Raised inflammatory markers suggesting of bacterial infection with either increased white cell count or C-reactive protein, or both Exclusion Criteria: * Nosocomial pneumonia which is acquired \>= 48 hours after hospital admission. Pneumonia which are already known to be caused by pathogens other than pneumococcus pneumoniae.
Where this trial is running
Shatin
- Department of Medicine and Therapeutics, Prince of Wales Hospital, CUHK — Shatin, Hong Kong (Recruiting)
Study contacts
- Study coordinator: KW To, MBChB
- Email: tokw617@yahoo.com.hk
- Phone: 35052211
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.