Testing diuretics for kidney disease treatment
Efficacy of Diuretics in Kidney Disease
This study is testing if the diuretic Metolazone can help people with chronic kidney disease by comparing its effects to a placebo over two weeks.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Stanford University Academic / other |
| Locations | 2 sites (Palo Alto, California and 1 other locations) |
| Trial ID | NCT04542304 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of diuretics in patients with chronic kidney disease through a cross-over design. Participants will experience two one-week periods, one receiving the diuretic Metolazone and the other a placebo, with a washout period in between. Blood and urine samples will be collected to assess changes in urine output, kidney clearance, and levels of uremic solutes. Daily weight monitoring and quality of life questionnaires will also be part of the assessment.
Who should consider this trial
Good fit: Ideal candidates include stable chronic kidney disease patients and stable dialysis patients who produce urine.
Not a fit: Patients with recent antibiotic use or those who have experienced instability in food intake may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment options for patients with chronic kidney disease.
How similar studies have performed: Other studies have explored diuretics in kidney disease, but this specific approach is less commonly tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * stable chronic kidney disease patients able to provide consent * stable dialysis patients who produce urine and able to provide consent Exclusion Criteria: * use of antibiotics for last two months or expected antibiotic use * recent hospitalization or other event resulting in instability of food intake
Where this trial is running
Palo Alto, California and 1 other locations
- Stanford University — Palo Alto, California, United States (Not_yet_recruiting)
- VA Palo Alto Health Care System — Palo Alto, California, United States (Recruiting)
Study contacts
- Study coordinator: Tammy L Sirich, MD
- Email: tsirich@stanford.edu
- Phone: 650-493-5000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.