Testing BLU-5937 for treating persistent cough in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, double-blind, placebo-controlled Phase 3 study evaluating the efficacy and safety of BLU-5937 in adults suffering from refractory chronic cough (RCC). The primary goal is to measure the impact of BLU-5937 on the frequency of coughing over a 24-hour period after 24 weeks of treatment. Participants will be randomly assigned to receive either the active medication or a placebo. The study aims to provide insights into a potential new treatment option for individuals with this challenging condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Capable of giving signed informed consent
* Refractory chronic cough (including unexplained chronic cough) for at least one year
* Women of child-bearing potential must use a highly effective contraception method during the study and for at least 14 days after the last dose

Exclusion Criteria:

* Current smoker/vaper (all forms of smoking and inhaled substances, including , cannabis/tobacco smoke and nicotine vapors) or individuals who have given up smoking within the past 6 months, or those with \>20 pack-year smoking history
* Diagnosis of Chronic Obstructive Pulmonary Disease (COPD), bronchiectasis, idiopathic pulmonary fibrosis or uncontrolled asthma
* Respiratory tract infection within 4 weeks before screening
* Laboratory confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection at screening
* History of malignancy in the last 5 years
* History of alcohol or drug abuse within the last 3 years
* Has a positive serologic test for human immunodeficiency virus (HIV), hepatitis B virus surface antigen, or hepatitis C virus.
* Previous participation in a BLU-5937 trial

Where it's running

• G & L Research, LLC
  Gulf Shores, Alabama, United States Recruiting
• California Allergy & Asthma Medical Group Inc.
  Los Angeles, California, United States Recruiting
• Southern California Institute For Respiratory Diseases, Inc.
  Los Angeles, California, United States Recruiting
• Paradigm Clinical Research Centers, Inc.
  Redding, California, United States Recruiting
• Precision Research Institute, LLC
  San Diego, California, United States Recruiting
• Allergy & Asthma Associates of Santa Clara Valley
  San Jose, California, United States Recruiting

+50 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: US GSK Clinical Trials call Center
• Email: GSKClinicalSupportHD@gsk.com
• Phone: 877-379-3718

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nalbuphine ER for chronic cough in people with RCC

  This study tests whether extended-release nalbuphine helps people with unexplained, long-standing cough that hasn’t improved with other treatments.

  Recruiting at 21 sites Phase 2 Trevi Therapeutics · Kelowna, British Columbia and 20 other locations · NCT07671924

• BLU-5937 for Refractory Chronic Cough: 24-Week Test in Adults (China Extension)

  This study tests whether BLU-5937 can reduce 24-hour cough frequency in adults with refractory or unexplained chronic cough.

  Recruiting at 38 sites Phase 3 GlaxoSmithKline · Leshan, Sichuan and 37 other locations · NCT07650084

• Cough Management app for refractory or unexplained chronic cough

  This trial will see if using a smartphone Cough Management program plus a smartwatch for four weeks lowers coughing and improves quality of life in adults 21–80 with refractory or unexplained chronic cough.

  Recruiting Hyfe Inc · Wilmington, Delaware · NCT07070895

• Behavioral Cough Suppression Therapy with or without an inhaled aid for refractory chronic cough

  This study tests whether adding an inhaled substance to behavioral cough suppression helps people with persistent chronic cough see if it works better than behavior therapy alone.

  Recruiting at 2 sites Phase 2 University of Montana · Aurora, Colorado and 2 other locations · NCT06960759

• Testing Duloxetine and Amitriptyline for Chronic Cough Relief

  This study is testing if two medications, Duloxetine and Amitriptyline, can help people with a stubborn chronic cough feel better.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT05110144

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.