Test different deep TMS coils and targets to treat OCD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with OCD are enrolled to compare sham deep TMS with two active coil targets (H7 and H1) in a double-blind, randomized design. Participants undergo baseline assessments and repeated symptom and safety evaluations, including neuroimaging analyses to explore neural mechanisms. The primary goal is to see if coil type and stimulation target produce different levels of symptom relief, with 96 participants in total divided equally among the three groups. The study excludes individuals with major psychiatric comorbidities, high suicide risk, significant medical conditions, neurological disorders, or MRI/PET incompatibilities. Recruitment is centered at Taipei Veterans General Hospital, Taiwan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-65 years.
* Diagnosis of obsessive-compulsive disorder according to DSM-5 criteria. Treatment resistance (i.e., inadequate response to pharmacological or non-pharmacological treatments) is not required.
* Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score ≥ 14, indicating at least mild to moderate symptom severity.

Exclusion Criteria:

* Diagnosis of schizophrenia, organic psychotic disorder, bipolar disorder, alcohol use disorder, or substance use disorder.
* High suicide risk within the past year.
* Presence of significant medical or surgical conditions in an active phase.
* History of, or planned, neurosurgical procedures, or presence of metallic implants in the brain or body (e.g., neurostimulators or cardiac pacemakers).
* Structural brain abnormalities (e.g., brain tumor or arteriovenous malformation) or neurological disorders (e.g., meningitis, encephalitis, stroke, or epilepsy).
* Pregnant women.
* Inability to tolerate PET/MRI examination due to claustrophobia or severe anxiety in confined spaces.
* Any other conditions that may impair study compliance, including inability to cooperate, failure to provide informed consent, or other investigator-determined ineligibility after screening.
* Use of medications that may increase seizure risk or suicide risk (e.g., certain antidepressants or antipsychotics).
* Known allergy to 18F-FDG (18F-2-Fluoro-2-DeoxyGlucose).
* History of adverse reaction to TMS or allergy to the positioning cap.
* Presence of metallic objects within approximately 30 cm of the cranial region (within the stimulation coil area).
* Prior or current treatment with electroconvulsive therapy (ECT) or vagus nerve stimulation (VNS).

Where it's running

• Taipei Veterans General Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Cheng-Ta Li
• Email: ctli0420@gmail.com
• Phone: 886-2-55704055

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.