Temporary Uterine Tourniquet vs Local Myometrial Epinephrine During Laparoscopic Myomectomy
Official title: Temporary Uterine Tourniquet Application Versus Local Myometrial Epinephrine Injection During Laparoscopic Myomectomy
Run by Minia University · NCT07525687 · Data updated 2026-11-12
This study tests whether a temporary uterine tourniquet works better or worse than injecting epinephrine into the uterine muscle to control blood loss during laparoscopic myomectomy in women with uterine fibroids.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 74 (estimated) |
| Sponsor | Minia University Academic / other |
| Locations | 1 site (Minya) |
| Status | Recruiting |
| Started | April 20, 2026 |
| Main results expected | January 20, 2027 |
| Study ends | January 20, 2027 |
| Registry record updated | July 21, 2026 |
| Trial ID | NCT07525687 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18-45 with symptomatic fibroids requiring laparoscopic myomectomy, having 1–3 fibroids sized 3–10 cm, and preoperative Hb ≥10 g/dL.
✕Probably not a fit
Patients with very large fibroids (>10 cm) or more than three fibroids, or those with certain medical conditions may not benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized comparison looks at two blood-loss control methods used in laparoscopic myomectomy: a temporary uterine tourniquet and local epinephrine injections in the myometrium. It aims to determine which approach provides better hemostasis with an acceptable safety profile. Eligible participants are women aged 18-45 with symptomatic fibroids requiring laparoscopic removal, within specified size and count criteria, and adequate preoperative hemoglobin. The trial excludes those with more than three fibroids, very large fibroids, bleeding disorders, major cardiovascular issues, infection, or prior extensive uterine surgery. Conducted at Minia University’s advanced laparoscopy unit, the study is designed to generate comparative data to guide surgical practice in this setting.
Why it matters
Potential benefit: If successful, the study could clarify which method better reduces blood loss during surgery, potentially improving recovery and safety for patients undergoing laparoscopic myomectomy.
How similar studies have gone: Prior research provides limited head-to-head comparisons of these approaches; this study addresses a gap with direct comparison in the laparoscopic setting, offering novel data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18-45 years. * Diagnosed with symptomatic uterine leiomyomas requiring laparoscopic myomectomy. * Presence of at least one myoma with a diameter ≥3 cm and ≤10 cm. * Patients with up to 3 myomas (to standardize surgical complexity). * Preoperative hemoglobin level ≥10 g/dL. * Ability to provide informed consent. Exclusion Criteria: * Patients with more than 3 myomas or any myoma larger than 10 cm. * Patients with suspected uterine malignancy (e.g., leiomyosarcoma). * Patients with known bleeding disorders or on anticoagulant therapy that cannot be safely discontinued. * Patients with significant cardiovascular disease, uncontrolled hypertension, or arrhythmias (relative contraindications for epinephrine). * Patients with active pelvic infection. * Patients with previous extensive uterine surgery (e.g., multiple prior myomectomies or extensive uterine reconstruction) that may compromise uterine integrity. * Patients undergoing concurrent major gynecological procedures that might significantly affect blood loss (e.g., hysterectomy, extensive adhesiolysis). * Patients with known allergy to epinephrine. * Patients unwilling or unable to comply with follow-up protocols.
Where it's running
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Minia advanced laparoscopy unit
Minya, Egypt Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Umbilico-uterine trunk clipping to lower blood loss during laparoscopic myomectomy
This will test whether temporarily clipping the umbilico-uterine trunk plus local epinephrine reduces bleeding during laparoscopic myomectomy in women aged 19–45 with up to four fibroids.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.