Telerehabilitation for cognitive impairment in multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on addressing cognitive impairment (CI) in individuals with multiple sclerosis (MS), a condition that significantly affects the quality of life and daily functioning. It employs a telerehabilitation approach, utilizing clinical assessments and cognitive evaluations to tailor interventions for participants. The study aims to improve cognitive functions such as information processing speed, attention, and memory through active procedures delivered remotely. Participants will be monitored and assessed using standardized cognitive tests to evaluate the effectiveness of the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female;
* Age 18-55 years;
* Native French speaking;
* Definite diagnosis of Relapsing-remitting MS (RRMS) according to McDonald 2017 criteria;
* Disease duration\> 12 months and ≤ 15 years;
* Computerized-Screening Cognitive Test (CSCT) score ≤ - 1.282 Standard Deviations (SD) (10th percentile) and/or cognitive complaint;
* 3 scores -1 SDa or 2 scores -1.5 SDb at least 2 of 5 baseline preselection neuropsychological battery tests in one of the following domains: processing speed or attention or working memory (SDMT, subtests alert, divided attention, visual scanning for selective attention, TAP and subtest working memory of the WAIS IV) and SDMT score not ≤ -3 SD;
* Able to use a computer with Windows operating system, an internet connection;
* Being affiliated to health insurance
* Having signed an informed consent (at the latest on the day of inclusion and before any examination required by research)

Exclusion Criteria:

* Previous history of other neurological disease;
* Psychiatric comorbidity including severe depression according to Diagnostic and Statistical Manual-IV (DSM-IV);
* Current dependence on alcohol or other addiction to toxic;
* Disabling visual or motor problems preventing participation to neuropsychological assessments;
* Change of psychotropic drug or disease-modifying therapies since less than one month;
* MS relapse in the month preceding the inclusion visit
* Illiteracy, ie: unable to count or to read;
* Acquisition disorders: dyslexia, dysphasia, dyscalculia and dyspraxia;
* Pregnant or breastfeeding women;
* Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).

Where it's running

• CHU de Bordeaux - Service de neurologie
  Bordeaux, France Recruiting
• CHU de Clermont-Ferrand - Service de neurologie
  Clermont-Ferrand, France Not yet recruiting
• CHU de Dijon-Bourgogne - Service de neurologie
  Dijon, France Not yet recruiting
• CH de Dunkerque - Service de neurologie
  Dunkerque, France Not yet recruiting
• Hôpital Saint Vincent de Paul - Service de neurologie
  Lille, France Not yet recruiting
• CHU de Montpellier - Service de neurologie
  Montpellier, France Not yet recruiting

Study contacts

• Principal investigator: Aurélie RUET, Prof — University Hospital, Bordeaux
• Study coordinator: Aurélie RUET, Prof
• Email: aurelie.ruet@chu-bordeaux.fr
• Phone: 05 56 79 55 21

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.