Targeted endodontic microsurgery for treating chronic tooth infections

Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars : a Randomized Controlled Trial

This study tests if a new type of surgery using a 3D-printed guide can better treat chronic tooth infections in lower back teeth compared to traditional methods.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 50 (estimated)
• Ages: 18 Years to 55 Years
• Sex: All
• Sponsor: Postgraduate Institute of Dental Sciences Rohtak (other)
• Locations: 1 site (Rohtak, Haryana)
• Trial ID: NCT06643676 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of targeted endodontic microsurgery using a 3D-printed surgical guide compared to conventional microsurgery techniques for treating chronic periapical diseases in mandibular molars. The procedure involves precise access to the root tip under high magnification, allowing for the removal of infected tissue while minimizing damage to surrounding anatomical structures. By utilizing advanced imaging and surgical guidance, the study aims to improve surgical outcomes and patient quality of life following treatment.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18-55 with specific endodontic lesions that have not responded to previous treatments.

Not a fit: Patients with vertical root fractures or other significant dental complications may not benefit from this procedure.

Why it matters

Potential benefit: If successful, this approach could lead to better healing outcomes and improved quality of life for patients suffering from chronic periapical conditions.

How similar studies have performed: Previous studies have shown that surgical guidance in endodontic procedures can significantly enhance accuracy and reduce complications, suggesting a promising outlook for this approach.

Eligibility criteria

Inclusion Criteria:

* Patients between 18-55 years of age
* No general medical contraindications for oral surgical procedures (ASA-1 according to the classification of the American Society of Anesthesiologists)
* ASA 1- A normal healthy patient. Example: Fit, non-obese (BMI under 30), a nonsmoking patient with good exercise tolerance.
* Tooth with a peri-radicular lesion of strictly endodontic origin (Symptomatic and Asymptomatic apical periodontitis) with the size of lesion 5mm≤10mm and intact cortical bony plate in CBCT
* Tooth with non-surgical retreatment unfeasible or previously failed (post, anatomy, or iatrogenic complications like irrepairable ledges, separated instruments and apical transportation) Tooth with adequate final restoration without clinical evidence of coronal leakage but with persisting periodontal lesion.
* No spontaneous pain or swelling
* Periodontically healthy teeth at tooth level.

Exclusion Criteria:

* Presence of vertical root fracture
* Presence of root perforations
* Miller class III/IV mobility
* Presence of root resorption
* Combined Endodontic-Periodontic lesions
* Pregnancy
* Patients with neuropsychiatric disorders and other systemic conditions
* Smokers.

Where this trial is running

Rohtak, Haryana

• Post Graduate Institute of Dental Sciences , Rohtak — Rohtak, Haryana, India (RECRUITING)

Study contacts

• Principal investigator: MOHAMMED MUZAFFAR KHAN, BDS — PGIDS ROHTAK HARYANA
• Study coordinator: mohammed muzaffar khan, BDS

Conditions: Periapical Diseases, Periapical Periodontitis, Periapical Cyst, Periapical Granuloma, Periapical Pathology, Endodontic Microsurgery, Targeted Endodontic Microsurgery