Target-controlled infusion (TCI) versus inhaled anesthesia for recovery after VATS
Prospective Observational Cohort Study Comparing Recovery Profiles After Target-Controlled Infusion Versus Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery
For adults having elective VATS, doctors will compare target-controlled infusion (IV) versus inhaled anesthesia to see if one leads to faster and smoother recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Istanbul University - Cerrahpasa Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Trial ID | NCT07288099 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational cohort following adults undergoing elective video-assisted thoracoscopic surgery (VATS) at a single medical center. Anesthesia will be given per routine practice as either target-controlled infusion (TCI) total intravenous anesthesia or conventional inhalational agents, with no randomization or extra interventions. Researchers will record perioperative and postoperative data including awakening and extubation times, Aldrete score progression, sedation and pain scores, intraoperative hemodynamics, drug doses, and early complications such as nausea and vomiting. The two anesthesia groups will be compared to identify differences in early recovery patterns as they occur in real clinical practice.
Who should consider this trial
Good fit: Adults aged 18–65 scheduled for elective VATS with ASA physical status I–III who can give informed consent are the intended participants.
Not a fit: Patients with ASA IV or higher, preoperative hemodynamic or respiratory instability, emergency surgeries, contraindications to standard anesthetics, or neurological/psychiatric conditions that interfere with recovery assessment are unlikely to benefit from this observational comparison.
Why it matters
Potential benefit: If clear differences are found, the results could help clinicians choose the anesthesia method that shortens recovery time or reduces early complications after VATS.
How similar studies have performed: Comparisons of TCI/TIVA versus inhalational anesthesia have been performed in other surgical settings with mixed results, while VATS-specific evidence remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 65 years Patients scheduled for elective video-assisted thoracoscopic surgery (VATS) ASA physical status I-III Able to provide informed consent Planned postoperative recovery in PACU and surgical ward Exclusion Criteria: * ASA IV or higher Hemodynamic or respiratory instability before surgery Known allergy or contraindication to commonly used anesthetic agents Neurological or psychiatric conditions that may interfere with recovery assessment Emergency surgeries Patients who decline participation
Where this trial is running
Istanbul, Istanbul
- Istanbul University Cerrahpasa Medical Faculty — Istanbul, Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: mert katılmış, md
- Email: mertkatilmis97@gmail.com
- Phone: +905346430560
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.