Taiwan Obstructive Sleep Apnea Cohort
Clinical Features of Obstructive Sleep Apnea Patients With Different Phenotypes
This project will recruit 7,000 people with obstructive sleep apnea in Taiwan to see if PSG-derived endotypes and clinical features predict future health outcomes by linking sleep tests with national health records.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 7000 (estimated) |
| Ages | 0 Years and up |
| Sex | All |
| Sponsor | China Medical University Hospital Academic / other |
| Locations | 1 site (Taichung, Taiwan) |
| Trial ID | NCT07302685 on ClinicalTrials.gov |
What this trial studies
The study will prospectively enroll 7,000 patients referred to the China Medical University Hospital sleep center from 2020–2027 and collect full-night polysomnography and clinical data, which will be linked to the National Health Insurance Research Database. Polysomnography parameters will be used to derive endotypic traits such as measures of airway collapsibility, loop gain, arousal threshold, and muscle compensation. The investigators will examine associations between clinical features, PSG-based endotypes, and subsequent health outcomes recorded in the national database. A subset of participants will be invited for additional testing including lung function, blood serum tests, arterial blood gas, and cognitive assessments to provide complementary phenotyping.
Who should consider this trial
Good fit: Adults referred by physicians to the China Medical University Hospital sleep center with suspected or diagnosed obstructive sleep apnea who can complete at least six hours of polysomnography are ideal candidates.
Not a fit: Patients who are not referred to this center, cannot complete the required six hours of PSG, or cannot consent to linkage with national health records are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this work could help identify patient-specific OSA endotypes that predict complications and guide more personalized treatment approaches.
How similar studies have performed: PSG-based endotyping has shown promise in smaller cohorts for characterizing OSA mechanisms, but large-scale prospective linkage to a national health database is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients who are referred to China Medical University Hospital sleep center by physicians Exclusion Criteria: -Individuals unable to complete at least 6 hours of PSG examination
Where this trial is running
Taichung, Taiwan
- China Medical University Hospital — Taichung, Taiwan, Taiwan (Recruiting)
Study contacts
- Study coordinator: Wan-Ju Cheng, Doctor
- Email: s871065@gmail.com
- Phone: +1872 +886422052121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.