Symptoms and quality of life in people with gastric inlet patches

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational, single-center study enrolling adults undergoing clinically indicated gastroscopy. Participants complete pseudonymized questionnaires about oropharyngeal and esophageal dysphagia, dyspepsia symptoms, and health-related quality of life before their procedure. Endoscopic findings will classify participants as having endoscopically confirmed heterotopic gastric mucosa (HGM) or not, and the study will compare symptom patterns and quality-of-life measures between these groups. An exploratory analysis will examine symptom differences by histologic subtype when routine histology is available.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Planned upper gastrointestinal endoscopy (gastroscopy) for clinical reasons (any indication)
* Age ≥ 18 years
* Written informed consent
* Ability to complete the study questionnaires prior to endoscopy

Exclusion Criteria:

* Previously known heterotopic gastric mucosa (HGM)
* Previously diagnosed dysphagia with prior therapeutic intervention (including pre-established diet modification, partial oral/enteral nutrition, steroid therapy, botulinum toxin injection, etc.)
* Mechanical ventilation
* Presence of a tracheostomy
* Inadequate endoscopic assessability of the proximal esophagus, including:
* General condition insufficient for careful endoscopic inspection (investigator's judgement)
* Increased risk of aspiration
* Inadequate visibility during the procedure (e.g., bleeding, food residue)
* Complications preventing careful inspection of the proximal esophagus
* History of surgery involving the pharynx or esophagus
* Relevant severe neurological disorder (e.g., ALS, stroke)
* Severe dementia
* Severe depressive disorder
* Lack of cooperation / inability to comply with study procedures
* Planned PEG placement
* Emergency endoscopy

Where it's running

• Knappschaftskrankenhaus Bottrop
  Bottrop, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Study coordinator: Felix Horstmann, MD
• Email: felix.horstmann@knappschaft-kliniken.de
• Phone: 02041151500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.