Switching from one heart medication to another for patients with acute coronary syndrome
Switching From Ticagrelor to Prasugrel in Patients With Acute Coronary Syndrome-a Stepped Wedge Cluster Randomized Evaluation in the SWEDEHEART-registry
PHASE4 · Vastra Gotaland Region · NCT05183178
This study is testing if switching heart medication from ticagrelor to prasugrel can help patients with acute coronary syndrome feel better after their hospital stay.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 16000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Vastra Gotaland Region (other gov) |
| Locations | 1 site (Lund) |
| Trial ID | NCT05183178 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of switching from ticagrelor to prasugrel in patients with acute coronary syndrome using a stepped-wedge cluster randomized design. The trial will involve multiple administrative regions in Sweden, where the order of switching medications will be randomly assigned. Initially, all regions will use ticagrelor, and after 9 months, one region will switch to prasugrel, continuing until all regions have made the switch. Patients will be monitored for at least 12 months following their hospitalization for acute coronary syndrome.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are hospitalized for acute coronary syndrome.
Not a fit: Patients on oral anticoagulation therapy or those with a history of stroke may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the more effective treatment options for patients with acute coronary syndrome.
How similar studies have performed: Other studies have shown success with similar approaches in evaluating medication efficacy in acute coronary syndrome, but this specific switch has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients hospitalized for Acute coronary syndrome, as defined by the European Society of Cardiology, at any hospital participating in the study, and included in the SWEDEHEART registry during index hospitalization * Age ≥ 18 years. Exclusion Criteria: * Patients on oral anticoagulation therapy * Previous stroke
Where this trial is running
Lund
- Dep. Cardiology, Skånes universitetssjukhus — Lund, Sweden (RECRUITING)
Study contacts
- Principal investigator: Elmir Omerovic, MD, PhD — Sahlgrenska Universitetssjukhus
- Study coordinator: Elmir Omerovic, MD, PhD
- Email: elmir@wlab.gu.se
- Phone: +46313422950
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Coronary Syndrome