Swiss Primary Sclerosing Cholangitis Cohort

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort that will enroll people with primary sclerosing cholangitis (PSC) across Swiss referral centers and collect standardized clinical data and biological samples for a biobank. Coded health-related personal data and biospecimens will be stored to enable longitudinal tracking of disease progression, treatment responses, and outcomes. The cohort provides a platform for multiple nested research projects and for collaboration with international PSC reference networks. No investigational treatments are given as part of this protocol; participation involves data collection and sample donation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed with PSC according to established criteria (European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of cholestatic liver diseases) of any age. Patients not fulfilling such criteria but still diagnosed with PSC in a hepatology referral centre can be included
* patients living in Switzerland

Exclusion Criteria:

* N/A

Where it's running

• Fondazione Epatocentro Ticino
  Lugano, Canton Ticino, Switzerland Recruiting
• Gastroenterologie und Hepatologie Clarunis - Universitäres Bauchzentrum Universitätsspital Basel
  Basel, Switzerland Recruiting
• Universitäts-Kinderspital beider Basel UKBB, Gastroenterologie&Ernährung
  Basel, Switzerland Recruiting
• Inselspital
  Bern, Switzerland Recruiting
• Kinderklinik, INSELSpital, Universität Bern, Pädiatrische Gastroenterologie, Hepatologie und Ernährung
  Bern, Switzerland Recruiting
• Spital Bülach
  Bülach, Switzerland Recruiting

Study contacts

• Study coordinator: Andreas Cerny, Prof. Dr. med
• Email: andreas.cerny@hin.ch
• Phone: +41 91 910 6570

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Biodegradable stents for high-grade bile duct strictures in PSC

  This study tests whether placing biodegradable stents helps open tight bile duct strictures in people with primary sclerosing cholangitis.

  Recruiting King's College Hospital NHS Trust · London · NCT07607353

• Vancomycin for active ulcerative colitis with primary sclerosing cholangitis

  This study tests whether oral vancomycin can help adults with both ulcerative colitis and primary sclerosing cholangitis more than a placebo over four weeks.

  Recruiting Phase 2 McMaster University · Hamilton, Ontario · NCT07341282

• Preventing recurrence of primary sclerosing cholangitis after liver transplantation

  This study is testing if a daily medication called fenofibrate can help prevent primary sclerosing cholangitis from coming back in people who have had a liver transplant.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06905054

• Colangioids to find genetic causes of atypical primary sclerosing cholangitis

  This project will use lab-grown bile duct organoids (colangioids) to test which genetic changes are linked to atypical primary sclerosing cholangitis in adults with confirmed or suspected PSC or in available liver tissue.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, MI · NCT06865924

• A breath test to detect liver cancer and monitor liver health

  This study is testing a new breath test to see if it can help find liver cancer earlier and keep track of liver health in adults with liver issues or certain stomach symptoms.

  Recruiting Imperial College London · London · NCT06864195

• Registry for autoimmune and cholestatic liver diseases in Spain

  This study is collecting information from patients with liver diseases in Spain to better understand these conditions and improve care for those affected.

  Recruiting Asociación Española para el Estudio del Hígado · Barcelona · NCT06767605

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.