Surface EMG measurement of swallowing and bolus preparation in eosinophilic esophagitis
sEMG Assessment of Swallowing and Bolus Preparation
This project will test whether surface EMG can measure swallowing and bolus preparation in adults with eosinophilic esophagitis compared with control participants.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT07156357 on ClinicalTrials.gov |
What this trial studies
This observational protocol records surface electromyography (sEMG) signals during standardized swallowing tasks and uses fiberoptic endoscopic evaluation of swallowing (FEES) or video swallow as baseline comparisons. Adult participants with histologically confirmed EoE (>15 eosinophils per high-power field) and control participants without dysphagia undergo sEMG during a test meal to capture muscle activity and bolus handling. Data will be compared between EoE and control groups to characterize differences in swallow biomechanics and bolus preparation. Findings aim to identify measurable sEMG patterns that could inform clinical monitoring or future interventions.
Who should consider this trial
Good fit: Ideal candidates are adults (over 18) with histologically confirmed EoE (>15 eos/hpf) who can safely eat a test meal, plus adults without dysphagia as control participants.
Not a fit: People with abnormal baseline video swallow, underlying neuromuscular disorders, or inability to coordinate eating likely will not benefit from the measurements in this protocol.
Why it matters
Potential benefit: If successful, this could provide a noninvasive way to detect or monitor swallowing problems in people with EoE and help personalize management.
How similar studies have performed: Surface EMG has been used successfully to study swallowing in other dysphagia populations, but its application specifically to EoE is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Controls * Normal video swallow or score of 0 for dysphagia on ESSAI questionnaire * absence of dysphagia * age \>18 EoE participants * Documentation of EoE diagnosis by histologic criteria, * \>15 eos/hpf on most recent esophageal biopsy * age \>18 Exclusion Criteria: * Abnormal baseline video swallow * lack of MSK coordination to eat test meal * underlying neuromuscular disorder.
Where this trial is running
Rochester, Minnesota
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Karthik Ravi, MD — Mayo Clinic
- Study coordinator: Ryan Alexander, MD
- Email: alexander.ryan2@mayo.edu
- Phone: 507-284-4824
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.