Support and care for people with psychosocial disabilities in Africa

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This initiative aims to provide comprehensive community-based interventions for individuals experiencing psychotic disorders in sub-Saharan Africa. It focuses on addressing not only the clinical symptoms of conditions like schizophrenia and delusional disorder but also the social challenges faced by these individuals, such as poverty and unemployment. The program is designed to empower participants through peer support and co-production, ensuring that interventions are culturally appropriate and accessible. The study will involve participants who are adults with a diagnosis of psychosis, utilizing both health records and diagnostic interviews for eligibility.

Why it matters

Who can join: the full rules

Inclusion criteria:

Participants with lived experience of psychosis must:

* Be consenting/assenting adults (age 18+)
* Be able to speak one of the main study languages: English, Chichewa, Krio, Shona, Yoruba
* Live within the pilot study area
* Have a current or past diagnosis of schizophrenia or other primary psychotic disorder, bipolar or depressive disorder with psychotic symptoms, or a maternal mental health or behavioural disorder with psychotic symptoms, as per the World Health Organisation's International Classification of Diseases Version 11 (see full list of eligible diagnoses, below).

For participants recruited from within the health care system, diagnosis will be confirmed from health records. For those identified in the community, a research worker will administer the World Health Organisation's Composite International Diagnostic Interview (WHO CIDI) screening tool for psychosis.

The following diagnoses are eligible for inclusion:

* Schizophrenia (6A20)
* Schizoaffective disorder (6A21)
* Schizotypal disorder (6A22)
* Acute and transient psychotic disorder (6A23)
* Delusional disorder (6A24)
* Other specified (6A2Y) or unspecified (6A2Z) primary psychotic disorder
* Bipolar type I disorder with psychotic symptoms (6A60.1, 6A60.5, 6A60.7, 6A60.A)
* Bipolar type II disorder with psychotic symptoms (6A61.3, 6A61.5)
* Single episode depressive disorder with psychotic symptoms (6A70.2, 6A70.4)
* Recurrent depressive disorder with psychotic symptoms (6A71.2, 6A71.4)
* Mental or behavioural disorder associated with pregnancy, childbirth or the puerperium, with psychotic symptoms (6E21)

Exclusion Criteria:

* People who are currently homeless, for logistical reasons; the SUCCEED intervention relies on PSWs and CSWs being able to regularly contact participants, including for home visits.
* People with secondary psychotic syndromes (6E61), as these are considered to be the direct consequences of physical health conditions as opposed to mental health conditions.
* People diagnosed with a substance-induced psychotic disorder (6C40.6-6C47.6), as recovery from substance use conditions is a specialist area outside the scope of the SUCCEED intervention under development.

Where it's running

• University of Makeni
  Makeni, Northen Province, Sierra Leone Recruiting
• University of Zimbabwe
  Harare, North East, Zimbabwe Recruiting
• Kamuzu University of Health Sciences
  Blantyre, Southern, Malawi Not yet recruiting
• University of Ibadan
  Ibadan, Oyo State, Nigeria Not yet recruiting

Study contacts

• Principal investigator: Professor Thomas Shakespeare — London School of Hygiene and Tropical Medicine
• Study coordinator: Dr Julian Eaton
• Email: julian.eaton@lshtm.ac.uk
• Phone: +44 77 11140365

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.