SuperCAP program to help cognition and daily functioning after COVID-19

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized study compares a 13-week digital intervention (SuperCAP) plus psychoeducation to standard care in people with post-COVID condition. Participants will complete sessions that combine cognitive training, fatigue self-management, and multidisciplinary content, followed by a 12-week observation period. The main goal is to see if SuperCAP reduces disability more than control, measured by a ≥5 point improvement on WHODAS 2.0 from baseline to post-intervention. Secondary aims include effects on quality of life, daily functioning, cognition, emotional well-being, durability of benefits, and feasibility of implementation. The study uses an app-based delivery (eSalut) and includes adults aged 18–65 with persistent cognitive symptoms after COVID-19.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of PCC, defined as the presence of three or more symptoms associated with COVID-19 infection for at least three months, not explained by other diseases.
* Age 18 to 65 years.
* Willingness to participate in an app-based intervention program aimed at improving daily Functioning in People Living with PCC.
* Evidence of patient-reported cognitive difficulties emerging after COVID-19, operationalized as a WHODAS 2.0 Cognition Domain (D1) score \> 6 at baseline via RedCAP.
* Digital proficiency defined as scoring ≥4 on MDPQ-16 item 2a (sending emails) and ≥3 on item 6a (using the device's app store) via RedCAP.
* Self-reported ability to use a mobile application for approximately 15 minutes per day, 5 days per week, considering their current symptoms.
* Possession of a personal smartphone compatible with the study mobile application (eSalut), with sufficient storage space and operating system version required for installation.

Exclusion Criteria:

* Inability to undergo neuropsychological tests or additional assessments.
* Prior use of the SuperCAP program.
* Current participation in a trial or program aimed at improving PCC symptoms.
* Any condition that, in the investigator's opinion, could make participation unsafe, complicate interpretation of study results, interfere with achievement of study objectives, or otherwise affect the participant's ability to complete the study.

Where it's running

• Fundació Lluita contra les Infeccions - Hospital Universitari Germans Trias i Pujol
  Badalona, Barcelona, Spain Recruiting

Study contacts

• Principal investigator: Anna Prats, PhD — Fundació Lluita contra les Infeccions
• Study coordinator: Anna Prats, PhD
• Email: aprats@lluita.org
• Phone: +34934657897

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.