Sulforaphane for Children Aged 6 to 12 With ADHD
Official title: Study of the Efficacy of Sulforaphane in Children Aged 6 to 12 With Attention Deficit Disorder With or Without Hyperactivity
Run by Assistance Publique - Hôpitaux de Paris · NCT06594536 · Data updated 2026-11-12
This study tests whether sulforaphane from broccoli helps reduce inattention and hyperactivity in children with ADHD compared with a placebo.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years to 12 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | December 1, 2024 |
| Main results expected | August 1, 2027 |
| Study ends | September 1, 2027 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT06594536 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are children aged 6 to 12 with DSM-5 ADHD who can swallow capsules and are enrolled at participating centers.
✕Probably not a fit
Children with certain exclusions (e.g., broccoli allergy, recent stimulant use, autism spectrum disorder, intellectual disability) may not experience benefit or could be exposed to unnecessary risk.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind, placebo-controlled trial will compare sulforaphane to placebo in children aged 6 to 12 with ADHD. Participants will be followed for 8 weeks to measure changes in ADHD symptoms using parent-rated ADHD-RS scores, with secondary measures including social behavior, emotional regulation, and overall functioning. Assessments will occur at 2, 4, and 8 weeks, including teacher-reported measures and specific neuropsychological testing of attention and inhibition. The study is conducted at a Paris center with parental consent and standard eligibility criteria to ensure safety and scientific validity.
Why it matters
Potential benefit: If successful, children may experience reduced ADHD symptoms and improved daily functioning with a dietary-derived treatment option.
How similar studies have gone: Prior research with sulforaphane has shown potential in neurodevelopmental contexts, but evidence in ADHD is exploratory and emerging.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children aged 6 to 12 * Diagnosis of ADHD according to DSM-5 criteria (Diagnostic and Statistical Manual of Mental Disorders) * Followed or hospitalised in an investigating centre * Consent of holders of parental authority * Patient covered by health insurance (social security or CMU) * Patients able to swallow capsules Exclusion Criteria: * Allergy to broccoli * Psychotropic treatment including methylphenidate in the month prior to inclusion * Ongoing psychotherapeutic and/or psycho-educational treatment specific to ADHD * ASD (Autism Spectrum Disorder) according to DSM-5 criteria, intellectual disability (IQ\< 80) * Chronic neurological disease, epilepsy * Holders of parental authority under guardianship or curatorship * Previous intake of sulforaphane * Known hypothyroidism or current thyroid treatment * Participation in other interventional research involving the human person or being within the exclusion period following previous research involving the human person, where applicable * Patient under AME (state medical aid)
Where it's running
-
Robert Debre Hospital
Paris, France Recruiting
Study contacts
- Study coordinator: Eric ACQUAVIVA, PhD
- Email: eric.acquaviva@aphp.fr
- Phone: 0140034092
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.