Study on mental health issues during and after pregnancy in Guangzhou

Peripartum Mental Health Cohort Study in Guangzhou

Guangzhou Women and Children's Medical Center · NCT04499066

This study looks at how common mental health issues like depression and anxiety are for pregnant women in Guangzhou, to help find ways to better support mothers and their babies.

Quick facts

Study typeObservational
Enrollment3000 (estimated)
SexFemale
SponsorGuangzhou Women and Children's Medical Center (other)
Locations1 site (Guangzhou, Guangdong)
Trial IDNCT04499066 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate the incidence and development of mental health problems, such as depression and anxiety, during the peripartum period among pregnant women in Guangzhou. It will collect epidemiological and clinical data, along with biological specimens, to understand the trajectory of these mental health issues and identify risk factors. The goal is to develop a comprehensive prediction model for postpartum depression and explore its adverse outcomes, ultimately improving health interventions for mothers and their children.

Who should consider this trial

Good fit: Ideal candidates for this study are pregnant women under 20 weeks of gestation who plan to deliver at the Guangzhou Women and Children's Medical Center.

Not a fit: Patients with pre-existing heart disease, hypertension, diabetes, or those currently taking antidepressants may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to better screening and intervention strategies for peripartum mental health issues, improving outcomes for mothers and their children.

How similar studies have performed: Other studies have shown success in understanding peripartum mental health issues, but this specific approach focusing on Chinese women is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Pregnant women with \<20 weeks of gestation
2. Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
3. Permanent residents or families intended to remain in Guangzhou with their child for more than 3 years

Exclusion Criteria:

1. Combined with heart disease, hypertension, diabetes or hyperthyroidism
2. Taking anti-depressants and other treatments for depression
3. Participants was in infection status when the biological samples were collected

Where this trial is running

Guangzhou, Guangdong

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Depression, Anxiety, Peripartum, Mental health, Risk factors, Pregnancy outcome, Cohort

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.