Study of brain activity during sleep using fMRI and EEG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to measure brain activity during sleep by utilizing functional magnetic resonance imaging (fMRI) in conjunction with electroencephalography (EEG). Healthy participants aged 18 to 34 will undergo a series of assessments, including physical and hearing exams, followed by all-night fMRI scans to observe brain activity in response to auditory stimuli. The goal is to correlate fMRI findings with auditory arousal thresholds, thereby enhancing our understanding of sleep behavior and brain connectivity. This research addresses a gap in existing literature regarding the relationship between sleep and auditory arousal.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

  1. able to give informed consent;
  2. in good general heath;
  3. between the ages of 18 and 34 years;
  4. able to sleep on your back for several hours (with breaks).

EXCLUSION CRITERIA:

1. have a medical condition like diabetes or uncontrolled hypertension;
2. have a psychiatric or neurologic condition like depression or stroke;
3. have ever had a seizure;
4. have a sleep disorder like insomnia or sleep apnea;
5. work night shifts;
6. have metal in your body such as pacemakers, metal prostheses, or aneurysm clips that would make MRI scanning unsafe;
7. are pregnant or nursing;
8. drink too much caffeine (6 or more cups of coffee per day or 10 or more cups of caffeinated soda per day);
9. use too much alcohol (15 or more alcoholic beverages per week for men and 8 or more alcoholic beverages per week for women);
10. use too much nicotine (nicotine use within 30 minutes of waking);
11. are afraid of enclosed spaces;
12. have known hearing problems;
13. regularly use a prescription or over-the-counter drug to help you sleep or stay awake;
14. are an employee, contractor, or volunteer of the Laboratory of Functional and Molecular Imaging in the National Institute of Neurological Disorders and Stroke.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Jeffrey H Duyn, Ph.D. — National Institute of Neurological Disorders and Stroke (NINDS)
• Study coordinator: Susan C Guttman
• Email: fultons@mail.nih.gov
• Phone: (301) 451-9912

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.