Stress and anxiety around biopsy and treatment for suspected bone or soft tissue tumors
Official title: Comparative Evaluation of Psychological Stress and Anxiety Levels Before Biopsy, After Diagnosis, and During Treatment in Patients With Suspected Primary or Metastatic Bone or Soft Tissue Malignancy
Run by Istanbul University · NCT07727434 · Data updated 2026-11-12
This study will follow adults undergoing a biopsy for a suspected bone or soft tissue tumor to see how their stress and anxiety levels change before the biopsy, after receiving the diagnosis, and at treatment start.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Istanbul University Academic / other |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | July 20, 2026 |
| Main results expected | December 20, 2026 |
| Study ends | January 20, 2027 |
| Registry record updated | July 27, 2026 |
| Trial ID | NCT07727434 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older scheduled for a biopsy due to a suspected solid tumor involving bone or soft tissue, able to complete questionnaires and provide consent.
✕Probably not a fit
Patients with advanced psychiatric conditions or cognitive/communication barriers that prevent valid questionnaire completion may not benefit from study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center observational study at Istanbul University. About 100 adults scheduled for a clinically indicated biopsy for suspected solid tumors of bone or soft tissue will be enrolled. Psychological assessments (Hospital Anxiety and Depression Scale, Perceived Stress Scale, and Distress Thermometer) are collected at three fixed time points: before biopsy, after the pathology result is explained, and at treatment initiation. Researchers will compare within-person changes across these time points and explore associations with demographics, disease stage, metastasis, and treatment type. No additional invasive procedures or interventions are performed for research purposes beyond routine care.
Why it matters
Potential benefit: If the study identifies when psychological distress peaks, it could inform supportive care timing for patients facing biopsy and treatment decisions.
How similar studies have gone: Previous research using similar psychological measures in cancer populations has shown meaningful fluctuations in distress around diagnostic milestones, supporting the relevance of this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older. * Scheduled for biopsy because of a suspected solid tumor. * Able to understand and answer the study questionnaires. * Able and willing to provide written informed consent before study participation. Exclusion Criteria: * History of previous malignancy. * Current serious psychiatric disorder, including major depressive disorder or psychotic disorder. * Cognitive impairment or communication difficulty that prevents valid completion of the study questionnaires. * Severe general medical condition or need for emergency intervention that makes study participation inappropriate.
Where it's running
-
Istanbul University, Istanbul Faculty of Medicine, Department of Orthopedics and Traumatology
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Serkan Bayram, M.D. — Istanbul University
- Study coordinator: Serkan Bayram, M.D.
- Email: dr.serkanbayram89@gmail.com
- Phone: +90 535 384 1408
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.