Stenting blocked aorto-iliac arteries to lower blood pressure
Official title: Impact of Endovascular Treatment of Aorto-iliac Disease on Systemic Hypertension A Pilot Study Impact of Aorto-Iliac Occlusive Disease Treatment on Blood Pressure
Run by Rijnstate Hospital · NCT07070583 · Data updated 2026-11-12
This pilot will try stenting chronic aorto-iliac occlusions in adults to see if opening these blockages lowers central blood pressure and related heart stress markers.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Rijnstate Hospital Academic / other |
| Locations | 1 site (Arnhem) |
| Status | Recruiting |
| Started | March 30, 2026 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | April 3, 2026 |
| Trial ID | NCT07070583 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (>=18 years) with chronic infrarenal aortic and/or common iliac artery occlusions of total lesion length >=30 mm who need revascularization for chronic limb-threatening ischemia or disabling claudication and can give informed consent and adhere to follow-up are ideal candidates.
✕Probably not a fit
Patients with juxtarenal pathology (lesions <2 cm below the lowest renal artery), acute occlusions (e.g., acute Leriche syndrome), embolic disease, or hypertension unrelated to vascular obstruction are unlikely to benefit from this procedure in this context.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective pilot interventional study enrolling adults with chronic infrarenal aortic and/or common iliac artery occlusions who have a clinical indication for revascularization. Participants will undergo stent placement in the aorto-iliac region and will have central blood pressure and NT-proBNP measured before and after the procedure with scheduled follow-up visits. The trial focuses on lesions >=30 mm in length and excludes acute occlusions, juxtarenal pathology, and embolic disease. Outcomes will characterize short-term changes in afterload and biomarkers of intracardiac pressure following revascularization.
Why it matters
Potential benefit: If successful, stenting these aorto-iliac occlusions could lower central blood pressure and intracardiac afterload, potentially improving blood pressure control and reducing risk of heart failure events for affected patients.
How similar studies have gone: Prior reports and small series have shown blood pressure reductions after stenting in the descending aorta and some distal arterial beds, but prospective data specifically for aorto-iliac stenting are limited and this pilot aims to fill that gap.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Singed informed consent * Chronic occlusion in the infrarenal aorta and/or one or both common iliac arteries * Total lesion length of ≥30mm * Clinical indication for treatment of the pathology (Chronic limb threatening ischemia or disabling intermittent claudication not responding to supervised exercise training) Exclusion Criteria: * Patient is unable to understand the study requirements and/ or is unwilling to adhere to the follow-up * Juxtarenal pathology (\<2cm below the lowest renal artery) * Acute occlusion of the target area (Acute Leriche Syndrome) * Embolic disease
Where it's running
-
Rijnstate
Arnhem, Netherlands Recruiting
Study contacts
- Study coordinator: Michel Reijnen, prof.dr.
- Email: vascularsurgery@rijnstate.nl
- Phone: 0031 88 005 7282
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.