STAND-UP: opening narrowed veins above the heart to help low blood pressure when standing
Official title: Evaluation of Supracardiac Venous Angioplasty and Stenting on Ortho- Static Intolerance and Orthostatic Hypotension - The STANDUP Study
Run by St. Francis Hospital, New York · NCT07195903 · Data updated 2026-11-12
This study will try a minimally invasive catheter procedure to open narrowed supracardiac veins and see if that improves dizziness, fainting, or low blood pressure in adults with orthostatic hypotension or orthostatic intolerance that hasn't improved with standard treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | St. Francis Hospital, New York Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Roslyn, New York) |
| Status | Recruiting |
| Started | January 23, 2025 |
| Main results expected | January 1, 2029 |
| Study ends | January 1, 2030 |
| Registry record updated | September 29, 2025 |
| Trial ID | NCT07195903 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with diagnosed orthostatic hypotension or orthostatic intolerance not adequately helped by standard treatments or complicated by supine hypertension, who can consent and undergo imaging and catheter procedures, are the intended participants.
✕Probably not a fit
Patients without demonstrable supracardiac vein narrowing, those who are pregnant or breastfeeding, people with active infection or coagulopathy, or those whose symptoms are well controlled on current therapies are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study enrolls 100 adults with orthostatic hypotension or orthostatic intolerance that is refractory to standard medical therapy or complicated by high blood pressure when lying down. Participants undergo imaging (X-ray, ultrasound) to look for narrowed veins above the heart and, if narrowing is found, may receive endovascular angioplasty or stenting via a catheter. Patients are followed for two years to track standing blood pressure control, symptom changes, and procedure safety, including monitoring for supine hypertension and vascular complications. The trial is single-center and targets people whose symptoms persist despite usual care.
Why it matters
Potential benefit: If successful, opening narrowed supracardiac veins could improve standing blood pressure and reduce dizziness, fainting, and fatigue for patients with refractory orthostatic disorders.
How similar studies have gone: Prior work on opening central veins for orthostatic symptoms is limited to small case series and pilot reports that suggest possible symptom improvement but lacks large randomized evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria : 1. Age 18 years 2. Diagnosed orthostatic intolerance or orthostatic hypotension not responding to standard medical management or complicated by supine hypertension 3. Able to provide informed consent • Exclusion criteria: 1\. Pregnancy or breastfeeding 2. Active infection 3. Coagulopathy or contraindication to anticoagulation therapy
Where it's running
-
St. Francis Hospital The Heart Center
Roslyn, New York, United States Recruiting
Study contacts
- Principal investigator: Karthikeyan M Arcot, MD — St. Francis Hospital The Heart Center
- Study coordinator: Karthikeyan M Arcot, MD
- Email: karcot@intneuro.org
- Phone: 516-612-9409
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How age, sex, and a handgrip affect heart–vessel communication during low blood pressure
We will test whether simulated low blood pressure with and without a handgrip exercise changes how the heart and blood vessels communicate in healthy young and older men and women.
-
Epidural electrical stimulation to manage low blood pressure in Parkinson's disease
This study will try epidural electrical stimulation (ARC-IM) to see if it helps people with typical or atypical Parkinson's disease who have symptomatic orthostatic hypotension.
-
How transcutaneous spinal stimulation affects heart function and blood pressure during the first year after spinal cord injury
The team will try transcutaneous spinal cord stimulation to see if it helps stabilize blood pressure in adults (18–75) with recent high-level spinal cord injuries who have low blood pressure and orthostatic symptoms.
-
Adjusting the carbidopa/levodopa ratio to reduce orthostatic hypotension in MSA-P and Parkinson's
This trial will test whether changing the carbidopa-to-levodopa ratio can reduce standing-related low blood pressure and symptoms in people with Parkinson disease or parkinsonian-type multiple system atrophy who are taking dopaminergic medication.
-
Improving blood pressure control in children who faint
This study is testing if certain movements can help children aged 6-18 who faint feel better by improving their blood pressure and heart function compared to regular advice.
-
Assessing counterpressure maneuvers for preventing fainting in children
This study is testing if teaching children techniques to prevent fainting can help them avoid losing consciousness when they visit the emergency room.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.