STAND-UP: opening narrowed veins above the heart to help low blood pressure when standing
Evaluation of Supracardiac Venous Angioplasty and Stenting on Ortho- Static Intolerance and Orthostatic Hypotension - The STANDUP Study
This study will try a minimally invasive catheter procedure to open narrowed supracardiac veins and see if that improves dizziness, fainting, or low blood pressure in adults with orthostatic hypotension or orthostatic intolerance that hasn't improved with standard treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Francis Hospital, New York Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Roslyn, New York) |
| Trial ID | NCT07195903 on ClinicalTrials.gov |
What this trial studies
The study enrolls 100 adults with orthostatic hypotension or orthostatic intolerance that is refractory to standard medical therapy or complicated by high blood pressure when lying down. Participants undergo imaging (X-ray, ultrasound) to look for narrowed veins above the heart and, if narrowing is found, may receive endovascular angioplasty or stenting via a catheter. Patients are followed for two years to track standing blood pressure control, symptom changes, and procedure safety, including monitoring for supine hypertension and vascular complications. The trial is single-center and targets people whose symptoms persist despite usual care.
Who should consider this trial
Good fit: Adults aged 18 or older with diagnosed orthostatic hypotension or orthostatic intolerance not adequately helped by standard treatments or complicated by supine hypertension, who can consent and undergo imaging and catheter procedures, are the intended participants.
Not a fit: Patients without demonstrable supracardiac vein narrowing, those who are pregnant or breastfeeding, people with active infection or coagulopathy, or those whose symptoms are well controlled on current therapies are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, opening narrowed supracardiac veins could improve standing blood pressure and reduce dizziness, fainting, and fatigue for patients with refractory orthostatic disorders.
How similar studies have performed: Prior work on opening central veins for orthostatic symptoms is limited to small case series and pilot reports that suggest possible symptom improvement but lacks large randomized evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria : 1. Age 18 years 2. Diagnosed orthostatic intolerance or orthostatic hypotension not responding to standard medical management or complicated by supine hypertension 3. Able to provide informed consent • Exclusion criteria: 1\. Pregnancy or breastfeeding 2. Active infection 3. Coagulopathy or contraindication to anticoagulation therapy
Where this trial is running
Roslyn, New York
- St. Francis Hospital The Heart Center — Roslyn, New York, United States (Recruiting)
Study contacts
- Principal investigator: Karthikeyan M Arcot, MD — St. Francis Hospital The Heart Center
- Study coordinator: Karthikeyan M Arcot, MD
- Email: karcot@intneuro.org
- Phone: 516-612-9409
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.