Clinical trial Recruiting at 1 site Interventional Ages 5 to 18

Speech treatment for minimally verbal children with autism and speech disorders

Official title: Speech Treatment for Minimally Verbal Children With ASD and CAS

Run by MGH Institute of Health Professions · NCT05066178 · Data updated 2026-11-12

This study is testing if a special speech treatment can help minimally verbal children with autism speak more clearly by using fun activities and targeted practice.

More Autism Spectrum Disorder trials

Quick facts

Study typeInterventional
Ages5 Years to 18 Years
SexAll
Enrollment20 (estimated)
SponsorMGH Institute of Health Professions
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedMay 1, 2024
Main results expectedApril 30, 2030
Study endsNovember 30, 2030
Registry record updatedMarch 30, 2026
Trial IDNCT05066178 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are minimally verbal children diagnosed with both Autism Spectrum Disorder and Childhood Apraxia of Speech who can repeat at least two syllables.

Probably not a fit

Patients with poorly controlled seizures, additional sensory impairments, or significant behavioral challenges may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of Childhood Apraxia of Speech (CAS) on speech development in minimally verbal children with Autism Spectrum Disorder (ASD). It aims to determine if CAS-specific treatment can improve speech intelligibility in these children. The approach involves identifying a cohort of 20 children and providing them with 15 one-hour treatment sessions that incorporate play-based activities and motor learning principles. The treatment focuses on practicing specific words that align with each child's speech challenges, using various supportive cues to enhance their speech production.

Why it matters

Potential benefit: If successful, this treatment could significantly improve speech intelligibility in minimally verbal children with autism, enhancing their communication skills.

How similar studies have gone: While this approach is novel in its specific focus on CAS in minimally verbal children with autism, similar interventions for speech disorders have shown promise in other populations.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Meets criteria for Autism Spectrum Disorder
* Able to correctly repeat at least 2 syllables
* Meets criteria for Childhood Apraxia of Speech
* Lives in an environment where child is exposed to English at least 50% of the time

Exclusion Criteria:

* Poorly controlled seizures
* Factors such as blindness or deafness that contribute to minimally verbal status
* Lives in an environment where English is not spoken at least 50% of the time
* Child experiences behavioral challenges that preclude participation in the study

Where it's running

  • MGH Institute of Health Professions
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.