Source-monitoring abilities in people with bipolar disorder and other neuropsychiatric conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare source-monitoring performance in diagnostic groups and matched healthy controls using computerized reality-monitoring and internal-monitoring tasks that distinguish internally generated from externally derived events and imagined from performed actions. They plan to enroll five diagnostic groups (pre-dementia Alzheimer’s, Alzheimer’s disease, frontotemporal dementia, Lewy body/Parkinson-related disorders, and bipolar disorder) with 30 patients per group, and recruit 150 healthy controls matched for age, sex, and education. Performance will be related to known frontotemporal abnormalities, with the hypothesis that groups with frontotemporal dysfunction will show larger deficits and bipolar patients will show less marked impairment. Testing is done in person, with screening to exclude individuals with working memory deficits that prevent completing the tasks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects who gave their free and informed consent;
* Men and women;
* Aged 18 to 80;
* Having normal or corrected vision;
* Mastering the French language (read and spoken);
* All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of \<MMSE \<26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013).

Exclusion Criteria:

* Inadmissibility of the consent or refusal of the subject.
* Patients under guardianship

Where it's running

• Centre Hospitalier Le Vinatier
  Bron, Auvergne-Rhône-Alpes, France Recruiting

Study contacts

• Principal investigator: Jerome Brunelin, Phd — Centre Hospitalier Le Vinatier - CRNL - INSERM
• Study coordinator: Jerome Brunelin, Phd
• Email: jerome.brunelin@ch-le-vinatier.fr
• Phone: 00334 37 91 55 65

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.