Single-stapled colorectal anastomosis for left-sided colon surgery.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational multicenter study enrolls adults undergoing elective left-sided colorectal resections (sigmoid resection, left hemicolectomy, or partial mesorectal excision) who receive a single-stapled colorectal anastomosis and compares outcomes to a retrospective double-stapled cohort. The primary outcome is anastomotic leakage within 90 days, and secondary aims include feasibility and safety across open, laparoscopic, and robot-assisted approaches. Data are collected prospectively at several Swedish university hospitals and supplemented by medical-record review of eligible cases operated during 2023–2025. The study is non-randomized and focuses on real-world surgical practice across multiple centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Planned (elective) left-sided colorectal resection with creation of a colorectal anastomosis, including: Left hemicolectomy, and/or Sigmoid resection, and/or Partial mesorectal excision (PME).
* Benign or malignant indication.
* Prospective cohort: Ability to provide written informed consent.
* Retrospective cohort: Eligible patients operated during 2023-2025 at participating centers, identified through medical record review, meeting the same surgical inclusion criteria.

Exclusion Criteria:

* Total mesorectal excision (TME) (e.g., low rectal cancer surgery requiring TME).
* Non-left-sided colorectal resections (e.g., right-sided colectomy) or procedures outside the study-defined operations.
* Surgery not involving a colorectal anastomosis (e.g., end colostomy/Hartmann's procedure without anastomosis).
* Emergency/urgent colorectal resection (non-elective surgery).
* Prospective cohort: Inability to provide informed consent.

Where it's running

• Östra Sahlgrenska University Hospital
  Gothenburg, Sweden Recruiting
• Sunderby Hospital
  Luleå, Sweden Recruiting
• Skåne University Hospital
  Malmö, Sweden Recruiting
• Surgical Centre, Umeå University Hospital
  Umeå, Sweden Recruiting
• Uppsala University Hospital
  Uppsala, Sweden Recruiting

Study contacts

• Principal investigator: Oskar Grahn, MD, PhD — Umea University / Region Vasterbotten
• Study coordinator: Oskar Grahn, MD, PhD
• Email: oskar.grahn@umu.se
• Phone: +46907850000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.