Shrimp Sensitization and Allergy in Edible Insect Allergy
Official title: Shrimp Sensitization and Allergy Among Patients With Edible Insect Allergy
Run by Mahidol University · NCT07857187 · Data updated 2026-11-12
This study tests whether people 7 and older who are allergic to edible insects also show shrimp sensitization or shrimp allergy, by using tests and risk-based food challenges.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 7 Years and up |
| Sex | All |
| Enrollment | 19 (estimated) |
| Sponsor | Mahidol University Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Bangkok, Bangkoknoi) |
| Status | Recruiting |
| Started | August 30, 2026 |
| Main results expected | May 2027 |
| Study ends | June 2027 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT07857187 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 7 years or older with a documented allergy to one or more edible insects (silkworm, bamboo worm, or palm weevil).
✕Probably not a fit
Patients without edible insect allergy or those not suspected of shrimp cross-reactivity may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cross-sectional study enrolls 7+ year-olds with confirmed edible insect allergies to explore shrimp sensitization and clinical shrimp allergy. Participants will undergo skin testing, specific IgE, molecular assays, and immunoblot analyses, with risk-based oral food challenges to edible insects and white shrimp when appropriate. The goal is to characterize cross-reactivity between edible insects and shrimp and to help avoid unnecessary shrimp avoidance. Data will describe how often edible insect allergy corresponds to shrimp sensitization and true shrimp allergy. The study is conducted at Siriraj Hospital, Mahidol University in Bangkok.
Why it matters
Potential benefit: If successful, results could clarify cross-reactivity patterns and reduce unnecessary shrimp restrictions for patients with edible insect allergies.
How similar studies have gone: Prior work in allergy research has used similar testing and challenge approaches to map cross-reactivity, though this exact combination for edible insects and shrimp is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 7 years or older with a history of allergy to one or more of the following edible insects: silkworm, bamboo worm, or palm weevil. * Patients with a history of an acute allergic reaction to silkworm, bamboo worm, or sago palm weevil who meet at least one of the following criteria: 1. Development of clinical symptoms consistent with an acute allergic reaction within 2 hours after ingestion of the implicated edible insect, with evidence of sensitization confirmed by a positive skin prick test (SPT) to that edible insect; or 2. A positive oral food challenge (OFC) to the edible insect previously associated with allergic symptoms (silkworm, bamboo worm, or sago palm weevil). Exclusion Criteria: * Scombroidosis (histamine fish poisoning). * Currently receiving allergen immunotherapy. * Unable to comply with the study follow-up schedule. * Uncontrolled or severe asthma. * Cardiovascular disease. * Current use of beta-blockers, angiotensin-converting enzyme inhibitors (ACEIs), or angiotensin receptor blockers (ARBs). * Developmental delay or intellectual disability.
Where it's running
-
Siriraj hospital
Bangkok, Bangkoknoi, Thailand Recruiting
Study contacts
- Principal investigator: Punchama Pacharn — Mahidol University
- Study coordinator: Punchama Pacharn
- Email: punchama@gmail.com
- Phone: 024197000 Ext. 5670
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.