Clinical trial Recruiting at 1 site Interventional

Shortening antibiotic courses for common throat and chest infections in primary care with doctor–pharmacist teamwork and viral‑circulation updates

Official title: Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care: A Cluster-Randomized Trial

Run by University Hospital, Caen · NCT07359287 · Data updated 2026-11-12

This project will test whether giving primary care doctors and pharmacists extra information about circulating viruses plus a shared protocol helps shorten antibiotic courses for patients with common respiratory infections.

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Quick facts

Study typeInterventional
SexAll
Enrollment4500 (estimated)
SponsorUniversity Hospital, Caen
Academic / other
Locations1 site (Caen)
StatusRecruiting
StartedDecember 1, 2025
Main results expectedJune 1, 2026
Study endsSeptember 1, 2026
Registry record updatedJanuary 22, 2026
Trial IDNCT07359287 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Patients seen in participating primary care practices for upper or lower respiratory infections (for example angina, acute bronchitis, bronchiolitis, AECOPD, laryngitis, otitis, sinusitis, or community‑acquired pneumonia) are ideal candidates.

Probably not a fit

Patients under legal protection are excluded, and individuals with complicated infections requiring individualized longer antibiotic courses are less likely to benefit from standardized shorter durations.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cluster-randomized trial conducted in six primary care practices (24 physicians) affiliated with CHU Caen Normandie, with three practices randomized to a bimodal intervention and three to usual care. The intervention combines regular communication about the circulation of respiratory viruses and a multidisciplinary GP–pharmacist protocol to verify that prescribed antibiotic durations follow guidelines. The primary aim is to see if this package reduces the duration of antibiotic treatments for upper and lower respiratory tract infections. Eligible encounters include a wide range of acute respiratory diagnoses, and patients under legal protection are excluded.

Why it matters

Potential benefit: If successful, the approach could reduce unnecessary antibiotic exposure and its side effects while helping slow antimicrobial resistance.

How similar studies have gone: Previous antimicrobial stewardship and GP–pharmacist collaboration programs have shown reductions in antibiotic use, so this combines established strategies into a novel two‑part intervention.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- Patient seen in consultation for an upper or lower respiratory tract infection (Angina, Acute bronchiolitis, Acute bronchitis, COPD exacerbation (AECOPD), Laryngitis, Acute otitis media (AOM), Serous or congestive otitis, Viral respiratory infection (e.g., influenza), Community-acquired pneumonia (CAP), Rhinitis / Nasopharyngitis, Acute sinusitis)

Exclusion Criteria:

\- Patient under legal protection

Where it's running

  • CHU CAEN Normandie
    Caen, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.