Short-term intensive statin treatment to lower cholesterol after ischemic stroke
Official title: Effects of Short-term Intensive Statin Therapy on Lipid Levels in Patients With Ischemic Stroke or Large Artery Atherosclerosis: A Prospective Observational Study
Run by General Hospital of Shenyang Military Region · NCT07344610 · Data updated 2026-11-12
This study will see if a short course of higher-dose statins quickly lowers cholesterol in adults who recently had an ischemic stroke or have significant arterial stenosis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | General Hospital of Shenyang Military Region Academic / other |
| Locations | 1 site (Shenyang, Liaoning) |
| Status | Recruiting |
| Started | January 8, 2026 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | January 15, 2026 |
| Trial ID | NCT07344610 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with ischemic stroke within 14 days of onset or ≥50% intracranial/extracranial atherosclerotic stenosis who can start intensive statin therapy within 24 hours and provide informed consent.
✕Probably not a fit
People already on recent statin therapy, those using other lipid-lowering drugs, pregnant or lactating women, or patients with serious comorbidities and limited life expectancy are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study of adults with acute ischemic stroke or imaging-confirmed intracranial/extracranial atherosclerotic stenosis who start intensive statin therapy within 24 hours of admission. Patients will receive higher-dose atorvastatin or rosuvastatin for at least one week, and investigators will track changes in lipid levels over the short term. The study will analyze variability in lipid response and explore clinical and demographic factors that influence that response. Results are intended to help tailor short-term lipid management after stroke.
Why it matters
Potential benefit: If successful, the findings could help doctors personalize statin dosing soon after stroke to achieve faster and more reliable cholesterol lowering.
How similar studies have gone: Previous trials have shown that high-intensity statins lower LDL and stabilize plaques and can reduce recurrent stroke risk, but short-term variability in lipid response after acute stroke is less well described.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years; * Diagnosis of ischemic stroke (within 14 days of onset) confirmed by cranial CT/MRI; or imaging-confirmed intracranial/extracranial atherosclerotic stenosis (stenosis rate ≥ 50%); * Intensive statin therapy (e.g., atorvastatin 40-80 mg/day or rosuvastatin 20 mg/day) initiated within 24 hours of admission, with a planned continuous application for at least one week; * Signed informed consent form. Exclusion Criteria: * Use of statin therapy within 1 week prior to admission; * Receiving other lipid-lowering treatments; * Presence of other serious comorbidities (e.g., malignant tumors, end-stage heart failure) with an expected survival of \<1 year; * Pregnant or lactating women; * Participation in other drug clinical trials within 3 months; * Other conditions deemed unsuitable by the investigator.
Where it's running
-
Lu Wang
Shenyang, Liaoning, China Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.