Short-term effects of once-daily Advagraf plus sirolimus after kidney transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial gives de novo kidney transplant recipients a regimen of once-daily extended-release tacrolimus (Advagraf/Astagraf XL) combined with the mTOR inhibitor sirolimus (Rapamune) instead of standard mycophenolate (MMF). The study measures short-term outcomes including graft function, infection rates (notably late-onset CMV), and treatment adherence related to once-daily dosing. Key exclusions include kidney–pancreas transplants, BMI > 30, and any preexisting sensitization (cPRA > 0%). The protocol aims to determine whether this combination maintains good allograft outcomes while potentially reducing CNI-related toxicity and improving compliance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All Kidney transplant recipients

Exclusion Criteria:

* Kidney-Pancreas transplant BMI\>30 cPRA\>0%

Where it's running

• Nooshin Dalili
  Tehran, Iran Recruiting

Study contacts

• Principal investigator: Dalili — Sbmu
• Study coordinator: Pi
• Email: dr.nooshindalili@gmail.com
• Phone: 00989122404331

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.