Shenfu Injection to help wean and reduce ventilator dependence in adults on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial enrolls adults on invasive mechanical ventilation to receive Shenfu Injection in addition to standard care or a control. Diaphragm function will be monitored daily with bedside ultrasound, assessing excursion and thickness. Primary goals include faster successful ventilator weaning and a lower need to resume ventilation within 48 hours after initial weaning. The study aims to determine if Shenfu can improve diaphragm performance and shorten dependence on mechanical ventilation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Critically ill patients requiring mechanical ventilation.
* Age \>18 years and \<75 years.
* No history of hypertension or diabetes mellitus.
* No history of allergy to traditional Chinese medicine injections.

Exclusion Criteria:

* Motor neuron disease.
* Guillain-Barré syndrome.
* Myasthenia gravis.
* Mitochondrial myopathy.
* Severe thoracic deformity.
* High cervical spinal cord injury or myelitis.

Where it's running

• The Fourth Affiliated Hospital, Zhejiang University School of Medicine
  Yiwu, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Min Li
• Email: 2504188@zju.edu.cn
• Phone: +8613588432932

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.