SGLT2 inhibitor after cardioversion to help keep sinus rhythm in AF with HFpEF

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center study randomizes 200 adults with persistent AF and HFpEF to receive an SGLT2 inhibitor or standard care after successful electrical cardioversion. Participants are stratified by AF duration and left atrial size and all receive anticoagulation and possible antiarrhythmic therapy per guidelines for at least one month. The primary outcome is recurrence of atrial tachyarrhythmia within 1 month, assessed by ECG or continuous monitoring. The trial uses an intention-to-treat analysis with a per-protocol sensitivity analysis and aims for about 90% power to detect a meaningful difference between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥19 years
* Persistent atrial fibrillation
* H2FPEF score ≥6 or HFA-PEFF score ≥5
* Restoration of sinus rhythm after electrical cardioversion

Exclusion Criteria:

* Previous use of an SGLT2 inhibitor
* Intracardiac thrombus on transesophageal echocardiography
* Refusal to participate

Where it's running

• Samsung Medical Center
  Seoul, Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Juwon Kim
• Email: abcd186a@naver.com
• Phone: +82-2-3410-2578

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.