Sex differences in left ventricular diastolic dysfunction and outcomes after cardiac surgery
Official title: The Effect of Left Ventricular DIastolic Dysfunction on Short Term Cardiac Surgery Outcomes in Female Cardiac patieNts
Run by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · NCT05972356 · Data updated 2026-11-12
This project will see if women with left ventricular diastolic dysfunction have different perioperative factors and 30-day outcomes than men when they undergo cardiac surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, North Holland) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | September 1, 2026 |
| Study ends | September 1, 2027 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT05972356 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 who underwent cardiac surgery at Amsterdam UMC between January 1, 2023 and December 31, 2026 and who do not object to reuse of their care data are eligible.
✕Probably not a fit
Patients who object to reuse of their care data or who had surgery outside Amsterdam UMC during the study period will not be included and therefore will not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center observational cohort using data from adults who had cardiac surgery at Amsterdam UMC between January 1, 2023 and December 31, 2026. Investigators will compare perioperative variables including body metrics, comorbidities, transesophageal echocardiography and hemodynamic measurements, transfusion and coagulation data, cardiopulmonary bypass factors, inotropic requirements, risk/outcome scores, and 30-day complications and mortality. Analyses will focus on differences between female and male patients with left ventricular diastolic dysfunction (LVDD/HFpEF) to identify patterns associated with worse outcomes in women. The overall aim is to identify actionable perioperative factors that could be targeted to improve outcomes for female cardiac surgery patients.
Why it matters
Potential benefit: If successful, the findings could help tailor perioperative care to reduce complications and deaths in women undergoing cardiac surgery.
How similar studies have gone: Previous observational work has identified sex-related differences in HFpEF and surgical outcomes, but few large perioperative datasets have specifically examined LV diastolic dysfunction in female cardiac surgery patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients \>18 years, who undergo cardiac surgery from 1 January 2023 till 31 December 2026 in the Amsterdam UMC Exclusion Criteria: * Patients who object to the re-use of their care data
Where it's running
-
Academic Medical Center
Amsterdam, North Holland, Netherlands Recruiting
Study contacts
- Principal investigator: Markus W Hollmann, Prof.Dr.Dr. — Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Study coordinator: Jennifer Breel, MSc,PhD
- Email: j.s.breel@amsterdamumc.nl
- Phone: +31(0)20 2566 2533
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.