Sevoflurane vs. Propofol for anesthesia in obese adults undergoing lumbar surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-center study assigns 70 adults with BMI 30–34.9 kg/m² to receive either sevoflurane-based inhalational anesthesia or propofol-based total intravenous anesthesia during elective lumbar instrumentation. All participants receive standardized induction with propofol, remifentanil, and rocuronium, with maintenance using either sevoflurane or propofol plus remifentanil under BIS monitoring. Blood samples are collected preoperatively, at 6 hours post-op, and at 24 hours post-op to measure pentraxin-3, serum amyloid A, and other inflammatory markers such as IL-6, TNF-α, CRP, glucose, and CBC parameters to explore immunomodulatory effects. The trial aims to clarify whether anesthetic technique modulates perioperative inflammation in obese patients, which could influence recovery and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged between 18 and 65 years
* Patients scheduled for elective lumbar instrumentation surgery
* Body mass index between 30 and 34.9 kg/m²
* Patients who provided written informed consent

Exclusion Criteria:

* Known allergy to inhalational or intravenous anesthetic agents
* Acute or chronic infectious disease
* Autoimmune disease or immunodeficiency
* Surgery within the last 3 months
* Chronic anti-inflammatory or immunomodulatory drug use
* Morbid obesity, defined as BMI \>35 kg/m²
* History of malignancy or active cancer treatment
* Renal failure, defined as GFR \<60 mL/min
* Liver failure, defined as AST or ALT greater than 2 times the upper limit of normal
* Diabetes mellitus, metabolic syndrome, or insulin resistance
* Pregnancy or lactation
* Neurological disease, including epilepsy, multiple sclerosis, or Parkinson's disease
* Alcohol or substance abuse
* Inability to comply with the study protocol or provide informed consent
* Known allergy to study drugs (propofol, sevoflurane, remifentanil)
* Emergency surgery

Where it's running

• Ataturk University
  Erzurum, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Mehmet Akif Yilmaz, Doctor
• Email: mehmetakifyilmaz025@gmail.com
• Phone: +905346533539

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.