Sepsis-related heart problems (myocarditis) in adults at Jimma University Medical Center
Official title: Cardiac Manifestations of Sepsis and Its Association With Disease Outcome: A Prospective Cohort Study
Run by Jimma University · NCT07079605 · Data updated 2026-11-12
See if sepsis-related heart problems affect recovery, functional capacity, and one-year survival in adults with sepsis at Jimma University Medical Center.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 226 (estimated) |
| Sponsor | Jimma University Academic / other |
| Locations | 1 site (Jimma, Oromiya) |
| Status | Recruiting |
| Started | May 9, 2025 |
| Main results expected | May 8, 2026 |
| Study ends | September 22, 2026 |
| Registry record updated | July 23, 2025 |
| Trial ID | NCT07079605 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 years or older admitted with sepsis at Jimma University Medical Center who have no pre-existing cardiac disease and agree to one-year follow-up.
✕Probably not a fit
Patients with established pre-existing cardiac disease are excluded and may not benefit from the study's findings, and those unable to complete follow-up may also not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cohort at Jimma University Medical Center will enroll adults (≥18 years) admitted with sepsis who have no prior cardiac disease and categorize them by presence or absence of sepsis-associated cardiac involvement using clinical signs, biomarkers (troponin, BNP), ECG and echocardiography. Participants will receive standard sepsis care and be followed for one year to measure persistence of cardiac abnormalities, functional capacity, and survival. Data will be collected with structured checklists and analyzed using Kaplan-Meier survival curves, log-rank tests, and regression models to identify predictors of adverse outcomes. The work aims to provide long-term outcome data from a resource-limited, single-center setting in Ethiopia.
Why it matters
Potential benefit: If successful, the findings could identify which sepsis patients need closer cardiac monitoring and targeted management to reduce mortality and long-term heart dysfunction.
How similar studies have gone: Previous research has documented acute sepsis-associated myocardial dysfunction, but long-term outcomes and predictors are less well-defined, especially in low-income countries.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All adult patients aged 18 years and above diagnosed with sepsis admitted to Jimma University Medical Center during the study periods that are willing to participate and continue follow-up of their disease condition for at least one year. Exclusion Criteria: * Patients with any kind of pre-existing established cardiac disease prior to their sepsis diagnosis and those who are not willing to participate or not willing to have follow-up of their disease condition for at least one year.
Where it's running
-
Jimma University Hospital
Jimma, Oromiya, Ethiopia Recruiting
Study contacts
- Study coordinator: Kedir Negesso Tukeni, MD, Internist, Cardiologist
- Email: Kedir.negesso@ju.edu.et
- Phone: 0913521475
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.