Clinical trial Recruiting at 1 site Interventional Ages 30 to 65 Women only

Self-sampling to improve cervical cancer screening attendance

Official title: Cervical Cancer Prevention Using Self-sampling and Human Papillomavirus Detection

Run by The Institute of Molecular and Translational Medicine, Czech Republic · NCT04226313 · Data updated 2026-11-12

This study is testing if sending self-sampling kits by mail, through gynecologists, or general practitioners can help more women in the Czech Republic get screened for cervical cancer.

Quick facts

Study typeInterventional
Ages30 Years to 65 Years
SexWomen only
Enrollment15000 (estimated)
SponsorThe Institute of Molecular and Translational Medicine, Czech Republic
Academic / other
Locations1 site (Olomouc)
StatusRecruiting
StartedSeptember 23, 2019
Main results expectedDecember 1, 2026
Study endsDecember 1, 2026
Registry record updatedMarch 23, 2026
Trial IDNCT04226313 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women aged 30-65 who have not participated in cervical cancer screening for at least three years and reside in the Czech Republic.

Probably not a fit

Patients who are pregnant, have no sexual intercourse experience, or have undergone a hysterectomy will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness of self-sampling and HPV testing to increase cervical cancer screening participation among under-screened women in the Czech Republic. It will compare three methods of providing self-sampling devices: by mail, through gynecologists, and via general practitioners. The study aims to determine the acceptability of self-sampling and its impact on screening attendance, while also analyzing sociodemographic factors. The goal is to address the low participation rates in cervical cancer screening and improve women's health outcomes.

Why it matters

Potential benefit: If successful, this approach could significantly increase cervical cancer screening rates and reduce the incidence of cervical cancer among under-screened women.

How similar studies have gone: Previous studies in several European countries have shown success with self-sampling approaches to increase cervical cancer screening attendance.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Women with age 30-65 years; for arm A women \> 65 years are allowed
* Women live in the Czech Republic.
* Women who have not participate in cervical cancer screening program in the Czech Republic for at least 3 years (Arm B and C).
* Women with completed informed consent.
* Women capable of self-sampling of cervicovaginal swab.

Exclusion Criteria:

* Pregnant women.
* Women with no sexual intercourse experience.
* Women after hysterectomy including cervix.

Where it's running

  • University Hospital Olomouc
    Olomouc, Czechia
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.