Seeing if CBD reduces the effects of THC

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 1, randomized, placebo-controlled human study at UCLA gives adults who use inhaled cannabis single doses of THC with or without one of several doses of oral CBD or placebo to see how CBD modifies THC's effects. Eligible participants are 21–55 years old, use cannabis 1–7 days per week, and meet medical and psychiatric screening criteria. Researchers will collect subjective effect ratings, pain response measures, cognitive and psychiatric assessments, and safety/laboratory monitoring during and after dosing. The protocol compares placebo, THC alone, and THC combined with 20 mg, 40 mg, or 80 mg CBD to characterize dose-related modulation of both adverse and analgesic effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or non-pregnant and non-lactating females aged 21-55 years
* Report cannabis use 1-7 days per week over the month prior to screening
* Not currently seeking treatment for their cannabis use
* History of inhaled cannabis use
* Have a Body Mass Index from 18.5 - 34 kg/m2
* Able to perform all study procedures
* Must be using a contraceptive (hormonal or barrier methods)

Exclusion Criteria:

* Meeting DSM-V criteria for severe Cannabis Use disorder (CUD) or any substance use disorder other than nicotine, caffeine, mild or moderate CUD
* Evidence of severe psychiatric illness (e.g. mood or anxiety disorder with functional impairment or suicide risk, schizophrenia) judged by the study physician (and PI) to put the participant at greater risk of experiencing adverse events due to completion of study procedures, interfere with their ability to participate in the study, or their capacity to provide informed consent.
* Report using other illicit drugs in the prior 4 weeks
* Current pain
* Pregnancy
* Currently enrolled in another research protocol
* Not using a contraceptive method (hormonal or barrier methods)
* Insensitivity to the cold water stimulus of the Cold Pressor Test
* Any disorders that might make cannabis administration hazardous as determined by evaluation physician after review of all medical assessments along with medical history.
* Not able to speak and read English

Where it's running

• UCLA Center for Cannabis and Cannabinoids
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Ziva Cooper, PhD — University of California, Los Angeles
• Study coordinator: Ziva Cooper, PhD
• Email: zcooper@mednet.ucla.edu
• Phone: 310-206-9942

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.