Screening for preeclampsia in early pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of first-trimester screening for preeclampsia using the FMF algorithm, which combines maternal clinical, sonographic, and biochemical parameters. By identifying women at risk for preeclampsia early in their pregnancy, the study seeks to improve maternal and perinatal health outcomes through targeted interventions. The screening will help determine the appropriate use of low-dose aspirin, which has been shown to significantly reduce the incidence of preeclampsia and its associated complications. The study will include pregnant women between 11 and 14 weeks of gestation who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria :

* Pregnancy between 11 and 14 WG
* Age ≥18 years
* Affiliated to or beneficiary of a health insurance system (including AME)
* Signed informed consent

Exclusion Criteria :

* Gestational age \<11 WG or \>14 WG
* Known ectopic pregnancy
* Known non-ongoing pregnancy
* Known multiple pregnancy
* History of PE in a previous pregnancy
* Pregnancies complicated by major fetal abnormality identified at the first-trimester ultrasound if performed before randomization
* Absence of health insurance
* Contra-indication to aspirin (bleeding disorders such as von Willebrand's disease, active peptic ulceration, hypersensitivity to aspirin, active peptic ulceration, NSAID-exacerbated respiratory disease, severe liver or heart dysfunction)
* Women taking low-dose aspirin regularly and started before pregnancy (except ART indication)
* Age \<18 years
* Poor understanding of the French language

Where it's running

• CHU Angers
  Angers, France Recruiting
• CHU de Bordeaux
  Bordeaux, France Recruiting
• Hôpital Femme Mère Enfant
  Bron, France Recruiting
• Hôpital Antoine Béclère
  Clamart, France Recruiting
• CHU Estaing
  Clermont-Ferrand, France Recruiting
• Hôpital Intercommunal Créteil
  Créteil, France Recruiting

Study contacts

• Study coordinator: Vassilis TSATSARIS, MD, PhD
• Email: vassilis.tsatsaris@aphp.fr
• Phone: 01 58 41 38 71

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Preeclampsia and normal pregnancy: retinal microcirculation using OCTA

  This study tests retinal blood flow in pregnant people with preeclampsia compared to healthy pregnant people using OCTA imaging.

  Recruiting Muğla Sıtkı Koçman University · Muğla, Menteşe · NCT07874191

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• Origins, features, and effects of preeclampsia on mother and baby

  This project will follow pregnant women diagnosed with preeclampsia through late pregnancy, delivery, and early postpartum to collect clinical data and biological samples to see how preeclampsia affects mothers and their babies.

  Recruiting Medical University of Graz · Graz · NCT07513558

• National first-trimester screening program to prevent preeclampsia in Denmark

  This program will try a new first-trimester screening for pregnant women with a single pregnancy in Denmark to find those at high risk of preeclampsia and offer early prevention such as low-dose aspirin.

  Recruiting at 3 sites Copenhagen University Hospital at Herlev · Aarhus and 2 other locations · NCT07485140

• Blood protein markers and heart changes in pregnant women with preeclampsia

  This study tests whether blood proteins can reveal early heart changes in pregnant women with preeclampsia and uses heart ultrasound to see how the heart changes during pregnancy.

  Recruiting Washington University School of Medicine · Abuja · NCT07463898

• Heart risk check for young women 3–6 years after pregnancy with or without placental complications.

  This project will test an app-based algorithm to see if it can identify cardiovascular risk in women 3–6 years after giving birth, including those who had preeclampsia or low-birth-weight infants.

  Recruiting Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07356817

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.