Screening for M-protein in relatives of multiple myeloma patients in China

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The CHAPERONE study aims to evaluate the clinical significance of screening for monoclonal gammopathy (M-protein) in first-degree relatives of patients with multiple myeloma in China. It will establish a prospective cohort of individuals with monoclonal gammopathy of undetermined significance (MGUS) and study the prevalence, progression, and influencing factors of this condition. Participants will undergo M-protein screening through serum electrophoresis, and those with detected M-protein will receive further diagnostic assessments and follow-up care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female over the age of 18;
2. First-degree relatives (including parents, children, and biological siblings) have multiple myeloma diagnosed by the International Myeloma Working Group (IMWG) Myeloma Diagnostic Criteria;
3. Understand the purpose and procedure of this trial and voluntarily participate in this screening study;
4. Participants should be willing and able to follow the study follow-up plan and other protocol requirements.

Exclusion Criteria:

Patients with a known diagnosis of plasma cell diseases, such as MGUS, smoldering myeloma (SMM), or multiple myeloma

Where it's running

• Zhongshan Hospital，Fudan University
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Peng Liu, PhD, MD — Fudan University
• Study coordinator: Peng Liu, PhD, MD
• Email: liu.peng@zs-hospital.sh.cn
• Phone: +8621-64041990

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.