Screening for abdominal and popliteal artery aneurysms
Screening for Abdominal Aortic Aneurysm and Popliteal Artery Aneurysm in At-risk Population (DAAP-PR Study)
This study is testing how common abdominal and popliteal artery aneurysms are in women over 65 who smoke and men over 65, to see if they need more screening for these serious conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 55 Years to 85 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Vaudois Academic / other |
| Locations | 2 sites (Castelfranco Veneto, TV and 1 other locations) |
| Trial ID | NCT05360108 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to evaluate the prevalence and characteristics of abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) through an opportunistic screening program using vascular ultrasound. It focuses on a female population aged 65 and older who are current smokers, as well as men aged 65 and older and individuals aged 55 and older with a family history of these aneurysms. The study seeks to fill the gap in data regarding the risk factors and epidemiology of these conditions, particularly in women, and assess the need for a dedicated screening program for PAA. The findings will provide valuable insights into the management and prevention of these potentially life-threatening conditions.
Who should consider this trial
Good fit: Ideal candidates include women aged 65 and older who are current smokers, men aged 65 and older, and individuals aged 55 and older with a family history of AAA or PAA.
Not a fit: Patients with a known diagnosis of AAA or PAA, those who have undergone surgery for these conditions, or those who have had recent screening or assessments will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening practices and early detection of aneurysms, potentially reducing morbidity and mortality associated with these conditions.
How similar studies have performed: While this study represents a novel approach to screening for PAA, similar studies on AAA screening have shown success in improving outcomes in men, indicating potential for positive results in this context as well.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged ≥65 years who are current smokers * Men aged ≥65 years * Women or Men aged ≥55 years with family history (first-degree relatives) for Abdominal Aortic Aneurysm (AAA) or popliteal artery aneurysm (PAA) Exclusion Criteria: * Patient with known diagnosis of AAA or PAA * Patient already operated for AAA or PAA * AAA/PAA screening or arterial assessment of lower limbs within the last 12 months * Inability to understand and/or sign study consent * Inability to access follow-up controls
Where this trial is running
Castelfranco Veneto, TV and 1 other locations
- Ospedale di Castelfranco Veneto, UOC Angiologia — Castelfranco Veneto, Tv, Italy (Recruiting)
- Centre Hospitalier Universitaire Vaudois (CHUV), Service d'Angiologie — Lausanne, Vd, Switzerland (Recruiting)
Study contacts
- Principal investigator: Adriano Alatri, MD — Centre Hospitalier Universitaire Vaudois
- Study coordinator: Adriano Alatri, MD
- Email: adriano.alatri@chuv.ch
- Phone: +41795565725
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.