Screening children for familial high cholesterol
Official title: Screening for Familial Hypercholesterolemia in Children
Run by Centre Hospitalier Universitaire, Amiens · NCT06555120 · Data updated 2026-11-12
We are testing a simple fasting blood screen to find familial high cholesterol in children ages 2 to 18.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 2 Years to 18 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Locations | 1 site (Amiens) |
| Status | Recruiting |
| Started | January 2, 2025 |
| Main results expected | August 2026 |
| Study ends | February 2027 |
| Registry record updated | February 12, 2026 |
| Trial ID | NCT06555120 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 2 to 18 who can fast at least 8 hours and whose parents and child (as appropriate) can give informed consent, with no prior diagnosis of familial hypercholesterolemia.
✕Probably not a fit
Children already diagnosed with familial hypercholesterolemia or those with recent-onset diabetes (under one month), profound hypothyroidism, acute nephrotic syndrome, or active cancer are unlikely to benefit from this screening.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional program uses a fasting blood sample to measure cholesterol and identify familial hypercholesterolemia in children aged 2–18. Parents and children provide informed consent before a minimum 8-hour fast and blood draw. Children with a known diagnosis of familial hypercholesterolemia or with recent-onset diabetes, profound hypothyroidism, acute nephrotic syndrome, or active cancer are excluded. The approach aims to improve diagnosis rates so affected children can start treatment early to reduce long-term cardiovascular risk.
Why it matters
Potential benefit: If successful, earlier diagnosis could allow treatment to lower LDL levels and substantially reduce lifetime cardiovascular risk.
How similar studies have gone: Screening and cascade testing for familial hypercholesterolemia in children have been implemented elsewhere and have successfully identified many affected individuals for early treatment.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 2 and 18 years * Minimum 8-hour fasting * Parents and children with signed informed consent Exclusion Criteria: * Known familial hypercholesterolemia * Diabetes less than one month old * Profound hypothyroidism * Acute nephrotic syndrome * cancer under treatment
Where it's running
-
CHRU Amiens
Amiens, France Recruiting
Study contacts
- Study coordinator: gwendoline Buissart, MD
- Email: buissart.gwendoline@chu-amiens.fr
- Phone: 0322838466
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.