Clinical trial Recruiting at 1 site Interventional Ages 2 to 18

Screening children for familial high cholesterol

Official title: Screening for Familial Hypercholesterolemia in Children

Run by Centre Hospitalier Universitaire, Amiens · NCT06555120 · Data updated 2026-11-12

We are testing a simple fasting blood screen to find familial high cholesterol in children ages 2 to 18.

Quick facts

Study typeInterventional
Ages2 Years to 18 Years
SexAll
Enrollment300 (estimated)
SponsorCentre Hospitalier Universitaire, Amiens
Academic / other
Locations1 site (Amiens)
StatusRecruiting
StartedJanuary 2, 2025
Main results expectedAugust 2026
Study endsFebruary 2027
Registry record updatedFebruary 12, 2026
Trial IDNCT06555120 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Children aged 2 to 18 who can fast at least 8 hours and whose parents and child (as appropriate) can give informed consent, with no prior diagnosis of familial hypercholesterolemia.

Probably not a fit

Children already diagnosed with familial hypercholesterolemia or those with recent-onset diabetes (under one month), profound hypothyroidism, acute nephrotic syndrome, or active cancer are unlikely to benefit from this screening.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program uses a fasting blood sample to measure cholesterol and identify familial hypercholesterolemia in children aged 2–18. Parents and children provide informed consent before a minimum 8-hour fast and blood draw. Children with a known diagnosis of familial hypercholesterolemia or with recent-onset diabetes, profound hypothyroidism, acute nephrotic syndrome, or active cancer are excluded. The approach aims to improve diagnosis rates so affected children can start treatment early to reduce long-term cardiovascular risk.

Why it matters

Potential benefit: If successful, earlier diagnosis could allow treatment to lower LDL levels and substantially reduce lifetime cardiovascular risk.

How similar studies have gone: Screening and cascade testing for familial hypercholesterolemia in children have been implemented elsewhere and have successfully identified many affected individuals for early treatment.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age between 2 and 18 years
* Minimum 8-hour fasting
* Parents and children with signed informed consent

Exclusion Criteria:

* Known familial hypercholesterolemia
* Diabetes less than one month old
* Profound hypothyroidism
* Acute nephrotic syndrome
* cancer under treatment

Where it's running

  • CHRU Amiens
    Amiens, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.