Screening children for familial high cholesterol
Screening for Familial Hypercholesterolemia in Children
NA · Centre Hospitalier Universitaire, Amiens · NCT06555120
We are testing a simple fasting blood screen to find familial high cholesterol in children ages 2 to 18.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 2 Years to 18 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens (other) |
| Locations | 1 site (Amiens) |
| Trial ID | NCT06555120 on ClinicalTrials.gov |
What this trial studies
This interventional program uses a fasting blood sample to measure cholesterol and identify familial hypercholesterolemia in children aged 2–18. Parents and children provide informed consent before a minimum 8-hour fast and blood draw. Children with a known diagnosis of familial hypercholesterolemia or with recent-onset diabetes, profound hypothyroidism, acute nephrotic syndrome, or active cancer are excluded. The approach aims to improve diagnosis rates so affected children can start treatment early to reduce long-term cardiovascular risk.
Who should consider this trial
Good fit: Children aged 2 to 18 who can fast at least 8 hours and whose parents and child (as appropriate) can give informed consent, with no prior diagnosis of familial hypercholesterolemia.
Not a fit: Children already diagnosed with familial hypercholesterolemia or those with recent-onset diabetes (under one month), profound hypothyroidism, acute nephrotic syndrome, or active cancer are unlikely to benefit from this screening.
Why it matters
Potential benefit: If successful, earlier diagnosis could allow treatment to lower LDL levels and substantially reduce lifetime cardiovascular risk.
How similar studies have performed: Screening and cascade testing for familial hypercholesterolemia in children have been implemented elsewhere and have successfully identified many affected individuals for early treatment.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 2 and 18 years * Minimum 8-hour fasting * Parents and children with signed informed consent Exclusion Criteria: * Known familial hypercholesterolemia * Diabetes less than one month old * Profound hypothyroidism * Acute nephrotic syndrome * cancer under treatment
Where this trial is running
Amiens
- CHRU Amiens — Amiens, France (RECRUITING)
Study contacts
- Study coordinator: gwendoline Buissart, MD
- Email: buissart.gwendoline@chu-amiens.fr
- Phone: 0322838466
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hypercholesterolemia, Familial, hypercholesterolemia, familial