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Screening and intervention program for high-risk cardiovascular patients in Hubei Province

High Risk Population of Cardiovascular Disease in Hubei Province (Coronary Heart Disease With Diabetes) Screening and Intervention Program

Not applicable Interventional Wuhan Union Hospital, China · NCT05782881

This study is testing a new treatment plan to see if it can help people over 40 with heart disease and diabetes in Hubei Province have fewer heart problems compared to standard care.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment16000 (estimated)
Ages40 Years to 75 Years
SexAll
SponsorWuhan Union Hospital, China Academic / other
Drugs / interventionschemotherapy
Locations107 sites (Enshi, Hubei and 106 other locations)
Trial IDNCT05782881 on ClinicalTrials.gov

What this trial studies

This program aims to evaluate the effectiveness of a protocol treatment group compared to conventional treatment in reducing the incidence of composite cardiovascular diseases among individuals aged 40 and older with coronary heart disease and type 2 diabetes. The study will recruit 16,000 participants from 14 prefecture-level cities in Hubei Province and will follow them for one year to assess various cardiovascular outcomes. Additionally, the program will investigate the genetic mechanisms underlying cardiovascular events and establish a prevention and control system for cardiovascular diseases in the region.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 40-75 with coronary heart disease and type 2 diabetes.

Not a fit: Patients with recent coronary stent treatment, severe cardiovascular complications, or other serious health conditions may not benefit from this program.

Why it matters

Potential benefit: If successful, this program could significantly reduce the incidence of serious cardiovascular events in high-risk patients.

How similar studies have performed: Other studies have shown success in similar interventions for cardiovascular disease management, indicating potential for positive outcomes.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. 40-75 years old, male or female
2. Patients with coronary heart disease complicated with type 2 diabetes (confirmed by angiography)
3. Low density lipoprotein cholesterol \>1.8mmol/l
4. Willing to participate and sign informed consent

Exclusion Criteria:

1. Received coronary stent treatment in recent one year
2. Pregnant or lactating women
3. Decompensated stage of chronic systolic heart failure (NYHA cardiac function rating ≥ 3), cardiac function; Patients with severe cardiovascular complications such as septic shock
4. Stroke patients in recent 1 year
5. Patients with severe gastrointestinal diseases, liver failure or kidney failure
6. Cancer patients or patients who have received radiotherapy or chemotherapy within five years
7. Suffering from infectious diseases such as AIDS and tuberculosis
8. Hospitalized or suffering from other serious diseases requiring immediate hospitalization
9. Bad addicts: drug users or alcoholics (men \>80 g / day, women \>40 g / day)
10. Disturbance of consciousness, inability to communicate normally or any mental illness; Those who are inconvenient to take care of themselves or move
11. Life expectancy \<12 months
12. Individuals with abnormal laboratory tests and clinical manifestations who are judged by the researcher to be unsuitable for participation
13. Unwilling to participate in the trial, unwilling to change the current drug treatment plan

Where this trial is running

Enshi, Hubei and 106 other locations

+57 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cardiovascular DiseasesDiabetes Mellitus, Type 2Coronary Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.