Same Day Ambulatory Appendectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of performing appendectomies on an outpatient basis, aiming to optimize patient care pathways and reduce hospital stays. It focuses on patients with uncomplicated acute appendicitis, assessing both the safety and quality of care in an outpatient setting compared to traditional inpatient procedures. The study seeks to enhance patient satisfaction by minimizing wait times in emergency departments and aims to lower healthcare costs associated with appendicitis treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 15-74 years
* BMI ≤ 35 kg/m2
* Uncomplicated acute appendicitis confirmed by imaging (ultrasound and/or CT and/or MRI)

  * Temperature ≤ 38,1°C and \> 35,5°C
  * Appendix diameter \> 6mm and ≤ 15mm
  * Without effusion or with only localized peri-appendicular effusion
  * Infiltration of peri-appendicular fat without abscess or plastron
  * No sign of perforation
  * Leukocytes ≤ 18,000G/L AND
  * CRP (C reactive protein) ≤ 60mg/L
* If pain, calmed by level 3 analgesic at maximum
* Ambulatory criteria

  * Availability of monitoring by a relative during the 12 hours after discharge from the hospital
  * Residence located less than 20 minutes by car from a health center (hospital or clinic)
  * Access to a telephone mobile or fixed in case of problems
* Signature of the written informed consent form by the patient
* If the patient is a minor, signature of the written informed consent form by both parents or their legal representative
* Affiliation to a French health insurance scheme or equivalent

Exclusion Criteria:

* Criteria that exclude ambulatory care such as an ASA score (Physical status score) \> 2, severe or uncontrolled comorbidities, severe pulmonary disease including obstructive sleep apnea, anticoagulation or antiplatelet drug or contraindication to ambulatory surgery such as intubation difficulties
* Presence of active cancer, a malignant hemopathy, drug addiction, coagulopathy, immunosuppressive treatment
* Non-acute or interval appendectomy, i.e. after antibiotic treatment of a complicated appendicitis of the plastron or drainage of an appendicular abscess;
* History of pelvic surgery
* Vulnerable people: pregnant or breast-feeding women (patients will undergo a pregnancy test: plasmatic β-hCG (human chorionic gonadotropin) or urinary test), adult under guardianship or deprived of freedom. Pregnant women are considered to have a full stomach, with risk of inhalation at anesthetic induction and represent a contraindication to ambulatory surgery. In addition, the need to perform abdominal surgery on a pregnant woman requires obstetric monitoring that is difficult to reconcile with management in an outpatient surgery unit (need for obstetric ultrasound or monitoring).
* Suspicion of a tumor of the appendix : Mucocele and pseudomyxoma, Carcinoid tumor, Adenocarcinoma of the appendix, Another type of tumor

Where it's running

• CHU de Nice
  Nice, Alpes-Maritimes, France Recruiting
• CHU Grenoble Alpes
  La Tronche, Auvergne-Rhône-Alpes, France Recruiting
• Hôpital Edouard HERRIOT
  Lyon, Auvergne-Rhône-Alpes, France Recruiting
• CHU de Saint-Etienne - Hôpital Nord
  Saint-Priest-en-Jarez, Auvergne-Rhône-Alpes, France Recruiting
• CH de Voiron
  Voiron, Auvergne-Rhône-Alpes, France Recruiting
• APHM Hôpital Nord
  Marseille, Bouches-du-Rhône, France Recruiting

Study contacts

• Study coordinator: Catherine ARVIEUX
• Email: catherine.arvieux@intradef.gouv.fr
• Phone: 04 43 98 52 42

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How PEG bowel preparation affects gut bacteria in people with or without an appendix

  This observational study will test whether polyethylene glycol colonoscopy prep changes gut bacteria differently in adults who have had an appendectomy compared with those who have not.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT07478029

• Closing the appendix stump with clips versus ties during laparoscopic appendectomy

  This study tests whether using metal clips or tying sutures to close the appendix stump during laparoscopic appendectomy leads to fewer complications and lower costs for people with acute appendicitis.

  Recruiting Sohag University · Sohag · NCT07115303

• Global assessment of appendicitis management outcomes

  This study looks at how appendicitis is treated in hospitals around the world to see if improvements can be made for all patients needing surgery.

  Recruiting at 4 sites University of Birmingham · Cotonou and 6 other locations · NCT06774001

• Using Fitbit to detect infections in children after appendectomy

  This study tests if using Fitbit data can help doctors spot infections early in children recovering from appendix surgery.

  Recruiting at 2 sites Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois and 3 other locations · NCT06395636

• Comparing Ketorolac and Morphine for Pain Relief in Children with Appendicitis

  This study is testing if ketorolac can help relieve pain just as well as morphine in children aged 6-17 who might have appendicitis.

  Recruiting Phase 3 University of Calgary · Calgary, Alberta · NCT06160778

• Comparing selective imaging methods to routine imaging for suspected appendicitis

  This study is testing if using specific imaging methods based on symptoms can help adults suspected of having appendicitis get better care compared to standard imaging methods.

  Recruiting at 3 sites Helsinki University Central Hospital · Espoo and 2 other locations · NCT06083064

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.