Safety of combining ropivacaine TAP block with intravenous lidocaine for colorectal cancer surgery
The Safety of Ropivacaine Transversus Abdominis Plane Block Combined With Intravenous Lidocaine in Patients Undergoing Colorectal Cancer Surgery: a Single Center, Open Label Dose Escalation Study
This study is testing if using a combination of two pain relief methods, ropivacaine TAP block and intravenous lidocaine, is safe for patients having colorectal cancer surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 9 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | West China Hospital Academic / other |
| Locations | 1 site (Chengdu) |
| Trial ID | NCT06006026 on ClinicalTrials.gov |
What this trial studies
This study investigates the safety of using ropivacaine transversus abdominis plane (TAP) block in conjunction with intravenous lidocaine infusion for patients undergoing colorectal cancer surgery. Both ropivacaine and lidocaine are local anesthetics that are commonly used for pain management in abdominal surgeries. The study aims to determine if the combination of these two analgesic techniques can be safely administered together, as their synergistic effects have not been previously established. By evaluating patient outcomes, the researchers hope to enhance multimodal analgesia protocols for colorectal surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 who are scheduled for open or laparoscopic colorectal cancer resection under general anesthesia.
Not a fit: Patients with significant cardiac or liver dysfunction, or those with allergies to the study drugs, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve pain management strategies for patients undergoing colorectal cancer surgery.
How similar studies have performed: While the individual use of ropivacaine and lidocaine has been studied, the combination's safety remains largely untested, making this a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Aged between 18 and 65 years; 2. Patients who plan to undergo open/laparoscopic colorectal cancer resection surgery under general anesthesia; 3. American society of Anesthesiologists (ASA) physical status classification system I\~II; Exclusion Criteria: 1. Weight less than 40kg or more than 100kg; 2. Defects in the cardiac conduction system (II or III degree atrioventricular block) or cardiac dysfunction (LVEF\<50%); 3. Severe liver dysfunction (ALT, AST, bilirubin 2.5 times higher than normal), renal dysfunction (creatinine clearance rate\<60ml/min); 4. Allergies to experimental drugs; 5. Patients who are unable to communicate; 6. Participating in other clinical researchers.
Where this trial is running
Chengdu
- West China hospital — Chengdu, China (Recruiting)
Study contacts
- Principal investigator: Weiming Li, PhD — West China Hospital
- Study coordinator: Chunling Jiang, PhD
- Email: jiangchunling@scu.edu.cn
- Phone: 18980601096
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.