Safety and tolerability of AB102 in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 1 trial enrolls healthy volunteers to evaluate the safety, tolerability, and pharmacokinetics of AB102 after single and multiple ascending oral doses. Participants are randomized to receive AB102 or placebo and are closely monitored for adverse events, lab changes, and vital signs. The study aims to characterize how AB102 is absorbed, distributed, metabolized, and excreted in the body. It also ensures eligibility criteria are met and safety data are collected to guide future research. The trial is conducted at a research site in Groningen under the lead sponsorship of Arcus Biosciences, with no collaborators listed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Understands the study procedures in the Informed Consent Form and is willing and able to comply with the protocol.
* BMI: 19.0 to 30.0 kg/m2, inclusive, at screening.
* All prescribed medication must have been stopped at least 30 days prior to admission to the clinical site. An exception is made for hormonal contraceptives that may be used throughout the study.
* Good physical and mental health based on medical history, physical examination, clinical laboratory, ECG, vital signs, and complete neurological examination, as judged by the Investigator.
* Participants must follow protocol-specified contraception guidance.

Exclusion Criteria:

* Have a history of relevant atopy, drug hypersensitivity and/or food allergies.
* Using tobacco products within 3 months prior to the screening.
* Have a significant infection or known inflammatory process on screening or admission.
* Have received any vaccination within 14 days of admission date for non-live vaccines or 28 days of admission date for live attenuated vaccines.
* History of alcohol abuse or drug addiction in the last 2 years (including soft drugs like cannabis products).

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Where it's running

• Research Site
  Groningen, Netherlands Recruiting

Study contacts

• Study coordinator: Medical Director
• Email: ClinicalTrialInquiry@arcusbio.com
• Phone: +1-510-462-3330

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effects of Exercise Snacks on Muscle Size and Strength in Healthy Young Adults

  This study tests whether many small workouts throughout the week can build muscle size and improve strength in healthy, untrained young adults compared with the usual twice-weekly workouts.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07760597

• ORX489 safety and dosing in healthy adults ages 18 to 60

  This will test whether ORX489 tablets are safe, well tolerated, and how they are processed in the body in healthy men and women aged 18 to 60.

  Recruiting Phase 1 Centessa Pharmaceuticals (UK) Limited · Lincoln, Nebraska · NCT07413666

• ReHIIT Prehabilitation in Healthy Adults

  This pilot tests a combined resistance and high‑intensity interval training program to establish baseline physiology in healthy adults before applying findings to cancer patients.

  Recruiting University of Nottingham · Derby, Derbyshire · NCT07313332

• Safety and drug levels of a 3‑month naltrexone implant (BICX104) with or without bupropion versus monthly Vivitrol injections

  This will test whether a three‑month naltrexone implant (BICX104), given alone or with extended‑release bupropion, is safe and keeps steady drug levels compared with monthly Vivitrol injections in healthy adults.

  Recruiting Phase 1 BioCorRx Pharmaceuticals Inc · Miami, Florida · NCT07269873

• Compare two forms and doses of vonafexor and see if the high dose interacts with other drugs

  This test looks at how two doses and two formulations of vonafexor (EYP651 and vonafexor acid) are absorbed and processed in healthy adults and whether the high dose interacts with common medicines.

  Recruiting Phase 1 Enyo Pharma · Gières · NCT07251153

• Low-frequency vibrating mat for sleep and daily stress recovery

  This test will see if using a low-frequency vibrating mat at home for three weeks improves stress recovery, sleep quality, mood, and attention in healthy adults aged 18-45.

  Recruiting Florida International University · Miami, Florida · NCT07221318

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.