Robotic-assisted versus conventional bronchoscopy for cryobiopsy to diagnose interstitial lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial assigns patients 1:1 to either conventional bronchoscopy with fluoroscopy-guided transbronchial lung cryobiopsy or robotic-assisted bronchoscopy with cone-beam CT guidance. In both arms four biopsies will be taken from two different lobes using a 1.7 mm cryoprobe. Biopsy location with RAB+CBCT allows real-time confirmation of sampling, while the conventional arm relies on 2D fluoroscopy for navigation. Histological specimens will be reviewed by a blinded multidisciplinary ILD board to determine diagnostic yield.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Clinical suspicion of interstitial lung disease requiring histological confirmation
* Non-diagnostic HRCT pattern (e.g. probable UIP or indeterminate pattern)
* Candidate for transbronchial lung cryobiopsy
* Ability to provide informed consent

Exclusion Criteria:

* Definite UIP pattern on HRCT
* Severe pulmonary hypertension
* Severe hypoxemia contraindicating bronchoscopy
* Coagulopathy or contraindication to biopsy
* Pregnancy
* Inability to provide informed consent

Where it's running

• Cantonal Hospital of Lucerne
  Lucerne, Canton of Lucerne, Switzerland Recruiting
• University Hospital Zurich
  Zurich, Canton of Zurich, Switzerland Recruiting

Study contacts

• Study coordinator: Thomas Gaisl, MD MPH PhD
• Email: thomas.gaisl@uzh.ch
• Phone: +41762318339

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.