Risk prediction model for frailty in elderly colorectal cancer patients
Development and Validation of a Risk Prediction Model for Preoperative Frailty in Elderly Patients With Colorectal Cancer
This study is trying to create a tool to help doctors predict frailty in older patients with colorectal cancer before surgery, to improve their care and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 364 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Zunyi Medical College Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Zunyi, Guizhou) |
| Trial ID | NCT05879861 on ClinicalTrials.gov |
What this trial studies
This study focuses on developing and validating a risk prediction model for preoperative frailty specifically in elderly patients diagnosed with colorectal cancer. Utilizing the Fried Scale and related assessments, the study analyzes various risk factors associated with frailty in this demographic. The model is constructed using R software and its effectiveness is verified through clinical practice, aiming to enhance preoperative evaluations and patient outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients aged 60 and above who have been diagnosed with colorectal cancer and are scheduled for surgery.
Not a fit: Patients with serious comorbidities, mental health issues, or those who have received preoperative treatments like chemotherapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this model could significantly improve preoperative assessments and care for elderly patients with colorectal cancer, leading to better surgical outcomes.
How similar studies have performed: While there have been studies on frailty in surgical patients, this specific approach to developing a risk prediction model for elderly colorectal cancer patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. patients who met the diagnostic criteria of colorectal cancer in Chinese Guidelines for Diagnosis and Treatment of Colorectal Cancer 2020 Edition and underwent surgery; 2. patients aged ≥60 years old ; 3. patients who are clearly conscious, able to understand instructions, communicate normally, and complete the physical activity ability test without the assistance of others; 4. patients who gave informed consent and volunteered to participate in the study. Exclusion Criteria: 1. patients with limb joint disease and lower limb pain; 2. patients with serious heart, liver, kidney diseases could not complete the test; 3. patients with visual impairment and hearing impairment; 4. patients with a history of mental illness or drug dependence; 5. taking antidepressants, levodopa/carbidopa, donepezil hydrochloride and other drugs ; 6. patients who received preoperative radiotherapy and chemotherapy; 7. Patients with hypothyroidism, Parkinson's disease, stroke and other diseases.
Where this trial is running
Zunyi, Guizhou
- Yongmei Zhang — Zunyi, Guizhou, China (Recruiting)
Study contacts
- Study coordinator: Yongmei Zhang
- Email: hulizym@yeah.net
- Phone: 13885257269
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.