Risk factors for rupture of flow-related aneurysms in posterior brain AVMs
Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.
The First Affiliated Hospital with Nanjing Medical University · NCT07050381
This project tries to find which clinical and imaging features make flow-related aneurysms in posterior brain arteriovenous malformations more likely to rupture in people with subarachnoid hemorrhage.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Sex | All |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University (other) |
| Locations | 2 sites (Nanjing, Jiangsu and 1 other locations) |
| Trial ID | NCT07050381 on ClinicalTrials.gov |
What this trial studies
This is an observational analysis of patients with posterior cerebral AVMs that have flow-related aneurysms, using digital subtraction angiography to identify aneurysms and CT to confirm subarachnoid hemorrhage. Investigators will collect clinical and imaging data from cases seen at two Nanjing hospitals and characterize features such as aneurysm size, location, and AVM angioarchitecture. They will compare patterns among ruptured versus non-ruptured presentations to identify factors associated with aneurysm rupture. No interventions are performed; the goal is to define risk markers that can inform clinical decision making.
Who should consider this trial
Good fit: Ideal candidates are patients with posterior brain AVMs who have flow-related aneurysms identified by DSA and a CT-confirmed subarachnoid hemorrhage, without a history of stroke, Marfan syndrome, or polycystic kidney disease.
Not a fit: Patients who do not have flow-related aneurysms, who lack adequate clinical or imaging records, or who have excluded conditions (for example Marfan syndrome or polycystic kidney disease) are not eligible and are unlikely to benefit from this analysis.
Why it matters
Potential benefit: If successful, the results could help doctors recognize which flow-related aneurysms on posterior AVMs are most likely to rupture and prioritize monitoring or treatment accordingly.
How similar studies have performed: Previous meta-analyses and cohort studies have reported higher hemorrhage rates when AVMs are accompanied by flow-related aneurysms, but focused analyses specifically on posterior AVMs and ruptured flow-related aneurysms remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT 2. No history of stroke, Marfan syndrome, polycystic kidney disease Exclusion Criteria: 1. pAVM without flow-related aneurysms 2. Absence of clinical data
Where this trial is running
Nanjing, Jiangsu and 1 other locations
- Jiangsu Province Hospital — Nanjing, Jiangsu, China (ACTIVE_NOT_RECRUITING)
- the First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (RECRUITING)
Study contacts
- Study coordinator: Yifei Wang
- Email: wangyifei5323@163.com
- Phone: +86-13852665323
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Arteriovenous Malformation of Central Nervous System, Aneurysm, Ruptured, Aneurysmatic Subarachnoid Haemorrhage, Aneurysm Cerebral, arteriovenous malformation, flow-related aneurysm, ruptured aneurysm, subarachnoid hemorrhage