Clinical trial Recruiting at 1 site Observational

Risk factors for rupture of flow-related aneurysms in posterior brain AVMs

Official title: Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.

Run by The First Affiliated Hospital with Nanjing Medical University · NCT07050381 · Data updated 2026-11-12

This project tries to find which clinical and imaging features make flow-related aneurysms in posterior brain arteriovenous malformations more likely to rupture in people with subarachnoid hemorrhage.

More Aneurysm Cerebral trials

Quick facts

Study typeObservational
SexAll
Enrollment200 (estimated)
SponsorThe First Affiliated Hospital with Nanjing Medical University
Academic / other
Locations2 sites (Nanjing, Jiangsu and 1 other locations)
StatusRecruiting
StartedJune 13, 2025
Main results expectedAugust 31, 2025
Study endsDecember 31, 2026
Registry record updatedJuly 3, 2025
Trial IDNCT07050381 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients with posterior brain AVMs who have flow-related aneurysms identified by DSA and a CT-confirmed subarachnoid hemorrhage, without a history of stroke, Marfan syndrome, or polycystic kidney disease.

Probably not a fit

Patients who do not have flow-related aneurysms, who lack adequate clinical or imaging records, or who have excluded conditions (for example Marfan syndrome or polycystic kidney disease) are not eligible and are unlikely to benefit from this analysis.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational analysis of patients with posterior cerebral AVMs that have flow-related aneurysms, using digital subtraction angiography to identify aneurysms and CT to confirm subarachnoid hemorrhage. Investigators will collect clinical and imaging data from cases seen at two Nanjing hospitals and characterize features such as aneurysm size, location, and AVM angioarchitecture. They will compare patterns among ruptured versus non-ruptured presentations to identify factors associated with aneurysm rupture. No interventions are performed; the goal is to define risk markers that can inform clinical decision making.

Why it matters

Potential benefit: If successful, the results could help doctors recognize which flow-related aneurysms on posterior AVMs are most likely to rupture and prioritize monitoring or treatment accordingly.

How similar studies have gone: Previous meta-analyses and cohort studies have reported higher hemorrhage rates when AVMs are accompanied by flow-related aneurysms, but focused analyses specifically on posterior AVMs and ruptured flow-related aneurysms remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
2. No history of stroke, Marfan syndrome, polycystic kidney disease

Exclusion Criteria:

1. pAVM without flow-related aneurysms
2. Absence of clinical data

Where it's running

  • the First Affiliated Hospital of Nanjing Medical University
    Nanjing, Jiangsu, China
    Recruiting
  • Jiangsu Province Hospital
    Nanjing, Jiangsu, China
    Active not recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.