Risk factors and health impact in people with genetic thoracic aortic disease
Official title: Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors.
Run by IRCCS Policlinico S. Donato · NCT07391293 · Data updated 2026-11-12
See how lifestyle, stress, reproductive history, and other health issues relate to risk and quality of life in people with genetic thoracic aortic aneurysms.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 14 Years to 60 Years |
| Sex | All |
| Enrollment | 208 (estimated) |
| Sponsor | IRCCS Policlinico S. Donato Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | May 6, 2025 |
| Main results expected | December 2026 |
| Study ends | May 2027 |
| Registry record updated | February 5, 2026 |
| Trial ID | NCT07391293 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with a genetic thoracic aortic aneurysm who can read, write, and speak Italian and are able to give informed consent are ideal candidates.
✕Probably not a fit
People without a genetic aortopathy, those who cannot communicate in Italian, or those needing immediate surgical intervention are unlikely to benefit directly from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational survey that collects clinical history and patient-reported information to map behavioural and cardiovascular risk profiles in people with genetic aortopathies. Data will include lifestyle factors, pregnancy-related events, menopausal status, psychological measures, eating disorders, and comorbid autoimmune or inflammatory bowel disease to explore how these factors interact. Information is gathered at IRCCS Policlinico San Donato using questionnaires and clinical records without experimental interventions. The goal is to define patterns that could inform improved risk stratification and supportive care for this population.
Why it matters
Potential benefit: If successful, the findings could help tailor monitoring and lifestyle or psychosocial support to reduce complications and improve quality of life for people with genetic aortic disease.
How similar studies have gone: Previous observational work has linked lifestyle and reproductive factors to aortic risk, but the combined role of psychological factors and autoimmune/inflammatory bowel disease in this population is relatively untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * signed onformed consent * Ability to speak, read and write in Italian Exclusion Criteria: \-
Where it's running
-
Irccs Policlinico San Donato
Milan, Italy Recruiting
Study contacts
- Study coordinator: Alessandro Pini, MD
- Email: alessandro.pini@grupposandonato.it
- Phone: +390252774705
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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GORE MBA Arch Endoprosthesis Early Feasibility Study
This study tests the safety of the MBA device in people with arch-related thoracic aortic diseases to see if it can be used safely in real-world settings.
-
See if spironolactone can reduce aortic stiffness in adults with thoracic aortic aneurysm
This study tests whether spironolactone reduces aortic stiffness compared with placebo in adults with degenerative thoracic aortic aneurysms.
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Evaluating outcomes of thoracic aortic repair in patients with compromised landing zones
This study is testing different stent-graft options for patients with aortic aneurysms who have tricky anatomy to see if they can prevent complications after surgery.
-
Advancing genomic medicine using electronic health records
This study is trying to see if using electronic health records and helpful reminders can get more patients tested for genetic conditions in a way that doctors can easily use.
-
Exploring genetic factors in acute aortic conditions
This study is testing whether looking at the genes of people with aortic dissection or aneurysm can help doctors better predict who is at risk and improve their chances of getting timely treatment.
-
Using presepsin levels to guide antibiotic treatment in thoracic aorta surgery patients
This study is testing if measuring a specific marker in the blood can help doctors give the right antibiotics to patients after thoracic aorta surgery to prevent infections and improve recovery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.