Risk factors and health impact in people with genetic thoracic aortic disease
Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors.
See how lifestyle, stress, reproductive history, and other health issues relate to risk and quality of life in people with genetic thoracic aortic aneurysms.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 208 (estimated) |
| Ages | 14 Years to 60 Years |
| Sex | All |
| Sponsor | IRCCS Policlinico S. Donato Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT07391293 on ClinicalTrials.gov |
What this trial studies
This is an observational survey that collects clinical history and patient-reported information to map behavioural and cardiovascular risk profiles in people with genetic aortopathies. Data will include lifestyle factors, pregnancy-related events, menopausal status, psychological measures, eating disorders, and comorbid autoimmune or inflammatory bowel disease to explore how these factors interact. Information is gathered at IRCCS Policlinico San Donato using questionnaires and clinical records without experimental interventions. The goal is to define patterns that could inform improved risk stratification and supportive care for this population.
Who should consider this trial
Good fit: Adults with a genetic thoracic aortic aneurysm who can read, write, and speak Italian and are able to give informed consent are ideal candidates.
Not a fit: People without a genetic aortopathy, those who cannot communicate in Italian, or those needing immediate surgical intervention are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, the findings could help tailor monitoring and lifestyle or psychosocial support to reduce complications and improve quality of life for people with genetic aortic disease.
How similar studies have performed: Previous observational work has linked lifestyle and reproductive factors to aortic risk, but the combined role of psychological factors and autoimmune/inflammatory bowel disease in this population is relatively untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * signed onformed consent * Ability to speak, read and write in Italian Exclusion Criteria: \-
Where this trial is running
Milan
- Irccs Policlinico San Donato — Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Alessandro Pini, MD
- Email: alessandro.pini@grupposandonato.it
- Phone: +390252774705
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.