Clinical trial Recruiting at 1 site Observational Ages 14 to 60

Risk factors and health impact in people with genetic thoracic aortic disease

Official title: Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors.

Run by IRCCS Policlinico S. Donato · NCT07391293 · Data updated 2026-11-12

See how lifestyle, stress, reproductive history, and other health issues relate to risk and quality of life in people with genetic thoracic aortic aneurysms.

Quick facts

Study typeObservational
Ages14 Years to 60 Years
SexAll
Enrollment208 (estimated)
SponsorIRCCS Policlinico S. Donato
Academic / other
Locations1 site (Milan)
StatusRecruiting
StartedMay 6, 2025
Main results expectedDecember 2026
Study endsMay 2027
Registry record updatedFebruary 5, 2026
Trial IDNCT07391293 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with a genetic thoracic aortic aneurysm who can read, write, and speak Italian and are able to give informed consent are ideal candidates.

Probably not a fit

People without a genetic aortopathy, those who cannot communicate in Italian, or those needing immediate surgical intervention are unlikely to benefit directly from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational survey that collects clinical history and patient-reported information to map behavioural and cardiovascular risk profiles in people with genetic aortopathies. Data will include lifestyle factors, pregnancy-related events, menopausal status, psychological measures, eating disorders, and comorbid autoimmune or inflammatory bowel disease to explore how these factors interact. Information is gathered at IRCCS Policlinico San Donato using questionnaires and clinical records without experimental interventions. The goal is to define patterns that could inform improved risk stratification and supportive care for this population.

Why it matters

Potential benefit: If successful, the findings could help tailor monitoring and lifestyle or psychosocial support to reduce complications and improve quality of life for people with genetic aortic disease.

How similar studies have gone: Previous observational work has linked lifestyle and reproductive factors to aortic risk, but the combined role of psychological factors and autoimmune/inflammatory bowel disease in this population is relatively untested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* signed onformed consent
* Ability to speak, read and write in Italian

Exclusion Criteria:

\-

Where it's running

  • Irccs Policlinico San Donato
    Milan, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.